Ecological determinants of paediatric tuberculosis in India

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-03-10 DOI:10.1016/j.ijtb.2025.02.018

Abhijit Mukherjee , Pallabi Dasgupta , Alapan Bandyopadhyay , Sharmistha Bhattacherjee

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引用次数: 0

Abstract

Background

Paediatric tuberculosis is a surrogate indicator of ongoing TB transmission. The present study explores the relationship between the burden of paediatric TB cases and their ecological determinants in different states of India.

Methods

Based on a conceptual model framework, an ecological record-based analysis was conducted using accessible national data from 33 Indian states and union territories. Based on the exploratory factors, negative binomial regression was performed to predict the number of paediatric tuberculosis cases.

Results

There was statistically significant geospatial clustering in paediatric TB incidence among states. Notification of paediatric cases was not affected by the size of the state. The rate of paediatric tuberculosis increased significantly by a factor of 1.004 and 1.107 for each unit increase in TB incidence per 100,000 population and the proportion of stunted children. The rate dropped significantly by a factor of 0.888 for each unit increase in chemoprophylaxis proportion. The rate of paediatric tuberculosis increases by 1.004, 1.100, and 1.899 times for every unit increase in BPL %, BCG coverage, and mean household size, respectively.

Conclusion

Adult TB case pool, malnutrition, overcrowding, and chemoprophylaxis are important predictors of variation in paediatric cases in India.

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印度儿童结核病的生态决定因素。

背景：儿童结核病是正在进行的结核病传播的替代指标。本研究探讨了印度不同邦儿童结核病病例负担与其生态决定因素之间的关系。方法：基于概念模型框架，利用来自印度33个邦和联邦属地的可获取的国家数据进行了基于生态记录的分析。基于探索性因素，采用负二项回归预测儿童结核病病例数。结果：各州儿童结核病发病率具有统计学意义的地理空间聚类性。儿科病例的通报不受国家规模的影响。每10万人口结核病发病率和发育迟缓儿童比例每增加1个单位，儿童结核病发病率显著增加1.004倍和1.107倍。化学预防比例每增加一个单位，发生率显著下降0.888倍。小儿结核病发病率每增加1个单位，分别增加1.004倍、1.100倍和1.899倍。结论：成人结核病例池、营养不良、过度拥挤和化学预防是印度儿科病例变化的重要预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline