Community-based assessment of Tuberculosis Preventive Therapy among household contacts living with index pulmonary TB patient in rural Delhi

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-02-03 DOI:10.1016/j.ijtb.2025.02.004

Sanjeev Kumar, Geeta Yadav, Shveta Lukhmana

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引用次数: 0

Abstract

Background

Latent tuberculosis infection (LTBI) poses a substantial risk for developing active TB, making TPT crucial for TB control. This study assesses the initiation and completion rates of TPT among household contacts of TB patients and reasons for non-initiation and non-completion.

Methods

A community-based cross-sectional study was conducted in areas served by the DOTS center under RHTC, Najafgarh. The study included 430 household contacts of pulmonary TB patients registered from January 2022 to December 2022. Participants were selected using a simple random sampling method.

Results

Out of 430 participants, 220 (51.2%) were aware of TPT and only 202 (46.9%) of all potential household contacts were screened for active TB. Among the aware HHCs (220), 188(85.4%) were initiated on TPT and among those who were initiated on TPT, 125(66.5%) completed their treatment. In comparison, 59(31.4%) were lost to follow-up, and 4(2.1%) discontinued due to side effects. The primary reason for non-initiation was not feeling the need for TPT 29(90.6%), and for non-completion of treatment, it was unavailability of medicine 32(50.8%).

Conclusion

There is a need for increasing awareness about TPT and a focus on systematic screening for TPT among HHCs of pulmonary TB patients. Proper implementation of government initiatives and monitoring are vital for improving TPT initiation and completion rates.

查看原文本刊更多论文

以社区为基础对德里农村地区与指数肺结核患者生活在一起的家庭接触者进行结核病预防治疗的评估。

背景：潜伏结核感染（LTBI）对发展为活动性结核具有重大风险，因此TPT对结核控制至关重要。本研究评估了结核病患者家庭接触者中TPT的开始和完成率以及未开始和未完成的原因。方法：以社区为基础的横断面研究在纳贾加尔省RHTC DOTS中心服务的地区进行。该研究包括从2022年1月到2022年12月登记的430名肺结核患者家庭接触者。参与者的选择采用简单的随机抽样方法。结果：在430名参与者中，220人（51.2%）知道TPT，只有202人（46.9%）对所有潜在的家庭接触者进行了活动性结核病筛查。在已知的hc（220例）中，188例（85.4%）开始了TPT治疗，其中125例（66.5%）完成了TPT治疗。相比之下，59例（31.4%）失去随访，4例（2.1%）因副作用停止治疗。未开始治疗的主要原因是感觉不需要TPT 29(90.6%)，未完成治疗的主要原因是无法获得药物32（50.8%）。结论：有必要提高对TPT的认识，并将重点放在系统性筛查肺结核hhc患者的TPT。政府举措的适当实施和监测对于提高TPT启动率和完成率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline