Multiparametric mapping of brain oxygen consumption with resting state calibrated functional MRI

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-09-18 DOI:10.1016/j.neuroimage.2025.121465

Antonio M. Chiarelli , Michael Germuska , Davide Di Censo , Ian Driver , Maria Eugenia Caligiuri , Hannah Thomas , Svetla Manolova , Hannah L Chandler , Alessandra Caporale , Emma Biondetti , Richard G. Wise

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引用次数: 0

Abstract

BOLD and cerebral blood flow (CBF) signal perturbations induced by isometabolic vasodilation enable the estimation of BOLD and CBF cerebrovascular reactivities (CVRs) and calibration of the BOLD signal through inference of its maximum change (M). We developed a BOLD and oxygen-transport modelling approach that uses a hypercapnic estimate of M to map the oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO₂). Inducing hypercapnia requires CO₂ inhalation or volitional breath-holding (BH). We present a calibrated fMRI framework aiming to overcome the limitations of induced hypercapnia that exploits endogenous resting-state (RS) modulations in brain hemodynamics. This approach was compared against BH. We derived a fitting regressor representing a non-metabolically demanding vascular signal from the average grey matter (GM) BOLD obtaining similar parametric maps between BH and a 10-min RS. Associations between average GM values were M: r=0.70, OEF: r=0.88, CMRO₂: r=0.94 (p-values<10⁻⁴) with slight underestimation of parameters derived from RS (∼10%) compared to BH. The most informative frequency range to extract a vascular regressor was in the high-frequency portion of the RS spectrum (oscillation times <20 s), where modulations in systemic pressure induced by breathing occur. RS fMRI estimation of CMRO₂ appears feasible, and it holds promise for research and clinical application.

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静息状态校准功能MRI脑氧消耗的多参数映射。

等代谢血管舒张引起的BOLD和脑血流量（CBF）信号扰动使BOLD和CBF脑血管反应性（CVRs）的估计和BOLD信号的校准通过其最大变化(M)推断。我们开发了一种BOLD和氧运输建模方法，该方法使用M的高碳酸估计来绘制氧提取分数（OEF）和脑氧代谢率（cmor2）。诱导高碳酸血症需要吸入二氧化碳或自愿屏气（BH）。我们提出了一个校准的fMRI框架，旨在克服诱导高碳酸血症的局限性，利用内源性静息状态（RS）调节脑血流动力学。该方法与BH方法进行了比较。我们从平均灰质（GM） BOLD中获得了一个代表非代谢要求血管信号的拟合回归量，在BH和10分钟RS之间获得了相似的参数图。平均GM值之间的相关性为M: r=0.70, OEF: r=0.88, cmoro2: r=0.94 (p值-4)，与BH相比，RS得出的参数略有低估（~ 10%）。提取血管回归因子的最有效的频率范围是RS频谱的高频部分（振荡次数2似乎是可行的），它有望用于研究和临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.