{"title":"Understanding miR-200c: an Important Player in Resistance to Cancer Treatment","authors":"Fatma Sanli, Omer Faruk Karatas","doi":"10.1002/adtp.202500238","DOIUrl":null,"url":null,"abstract":"<p>One of the biggest obstacles to successful cancer treatment is still therapeutic resistance, which frequently leads to recurrence and unsatisfactory clinical outcomes. MicroRNA-200c (miR-200c), one of several molecular regulators, has grown into a crucial modulator of treatment efficacy by affecting processes including apoptosis, drug efflux, epithelial-mesenchymal transition, and cancer stem cell properties. Despite extensive research on miR-200c's roles in drug resistance, there is lack of comprehensive reviews summarizing these findings. This review gathers the most recent data on the complex functions of miR-200c in mediating chemotherapy and radiotherapy resistance across various cancer types. Its potential clinical aspects as a biomarker and therapeutic target are further discussed. Finally, existing knowledge gaps are outlined, and future research directions are proposed to support development of miR-200c-based strategies for overcoming therapeutic resistance in cancer.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500238","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adtp.202500238","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
One of the biggest obstacles to successful cancer treatment is still therapeutic resistance, which frequently leads to recurrence and unsatisfactory clinical outcomes. MicroRNA-200c (miR-200c), one of several molecular regulators, has grown into a crucial modulator of treatment efficacy by affecting processes including apoptosis, drug efflux, epithelial-mesenchymal transition, and cancer stem cell properties. Despite extensive research on miR-200c's roles in drug resistance, there is lack of comprehensive reviews summarizing these findings. This review gathers the most recent data on the complex functions of miR-200c in mediating chemotherapy and radiotherapy resistance across various cancer types. Its potential clinical aspects as a biomarker and therapeutic target are further discussed. Finally, existing knowledge gaps are outlined, and future research directions are proposed to support development of miR-200c-based strategies for overcoming therapeutic resistance in cancer.