Correction to “Primaquine Analysis in Pharmaceutical Formulation Using Multiple and Short-End Injections by Capillary Zone Electrophoresis-Ultraviolet Detection”

Abstract

J. C. Q. de Souza, P. R. Chellini, M. V. N. de Souza, and M. A. L. de Oliveira, “Primaquine Analysis in Pharmaceutical Formulation Using Multiple and Short-End Injections by Capillary Zone Electrophoresis-Ultraviolet Detection,” Journal of Separation Science 47, no. 22 (2024): 1–11, https://doi.org/10.1002/jssc.70026.

The corrections to the article entitled “Primaquine Analysis in Pharmaceutical Formulation Using Multiple and Short-End Injections by Capillary Zone Electrophoresis-Ultraviolet Detection,” published in the Journal of Separation Science, DOI: 10.1002/jssc.70026 were considered. Thus, the corrections took into account errors in the following sections: Introduction, paragraph 2, and BGE Optimization, paragraph 2. Additionally, a correction was performed in Figure 1. The explanations for each corrected item have been described in detail.

In paragraph 2 of the “Introduction” section, the text “[…] the pKa₂ belongs to the nitrogen of pyridine moiety; […]” was incorrect. This should have read: “[…] the pKa₂ belongs to the nitrogen of the quinoline ring; […].”

In paragraph 2 of the “BGE Optimization” section, the text “The effective mobility versus pH curves in Figure 1B showed that the PQN is ionized up to pH 3.0, has a neutral behavior in the range of 4.0–10.0, and the anionic form becomes predominant at a pH above 11.0. So, PQN at pH values lower than pKa₂ behaves as a Lewis acid; at pH values between 4.5 and 9.5, approximately, it will have neutral behavior. Finally, above pH 10.4, it will behave as a Lewis base.” was incorrect. This should have read: “The effective mobility versus pH curves in Figure 1B show that PQN is doubly positively charged up to pH 3.2 (pKa₁), exhibits cationic behavior with a single positive charge in the pH range 4.0–10.0, and its neutral form becomes predominant at pH values above 10.4 (pKa₃). The expanded region of the first inflection point of the PQN curve, between 19.6 and 20.6 cm² V⁻¹ s⁻¹, is shown in Figure 1C.”

In Figure 1, Figure 1B is incorrect because the effective mobility versus pH curve of primaquine is incorrect. After recalculating the data, new mobility values were obtained, and the updated curve presents a very subtle inflection region. Therefore, the new Figure 1 should be divided into three parts: 1A—Primaquine structure and its pKa values; 1B—effective mobility versus pH curves for primaquine and background electrolyte components; and 1C—the expanded region of the first inflection point of the primaquine curve.″ The correct Figure 1 is shown below.

We apologize for these errors.