Pd(0)-Catalyzed (3 + 3) Annulation of Vinylcyclopropanes and Boronic Acid Derivatives: A Route to Vinyltetralones

IF 3.9 3区 化学 Q2 CHEMISTRY, PHYSICAL
ChemCatChem Pub Date : 2025-07-15 DOI:10.1002/cctc.202500775
Krishna Biswas, Dr. Sourav Mondal, Dr. Venkataraman Ganesh
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引用次数: 0

Abstract

Tetralones play a key role in numerous pharmacologically active compounds and as synthetic intermediates. We report a novel and efficient method for the synthesis of vinyltetralones via a palladium(0)-catalyzed (3 + 3) annulation between vinylcyclopropanes and 2-formyl phenylboronic acid derivatives. This strategy enables the construction of structurally diverse vinyltetralone frameworks under mild conditions. Control experiments were conducted to gain mechanistic insights into the annulation pathway, supporting the involvement of a π-allyl-palladium zwitterionic species in the catalytic cycle. Furthermore, the synthetic utility of the vinyltetralone products was demonstrated through downstream functionalization, highlighting their potential as valuable scaffolds for complex molecule synthesis. This methodology provides a powerful tool for the rapid assembly of tetralone motifs relevant to medicinal and materials chemistry.

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Pd(0)催化的乙烯基环丙烷和硼酸衍生物的(3 + 3)环化:乙烯基四酮的一条途径
四酮类在许多具有药理活性的化合物和合成中间体中起着关键作用。我们报道了一种新的、高效的方法,通过钯(0)催化(3 + 3)环在乙烯基环丙烷和2-甲酰基苯硼酸衍生物之间合成乙烯基四酮类化合物。这种策略能够在温和的条件下构建结构多样的乙烯四聚醚框架。通过对照实验获得环化途径的机理,支持π-烯丙基-钯两性离子参与催化循环。此外,乙烯四酮产品的合成用途通过下游功能化证明,突出了它们作为复杂分子合成有价值的支架的潜力。该方法为快速组装与药物和材料化学相关的四酮基序提供了有力的工具。
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来源期刊
ChemCatChem
ChemCatChem 化学-物理化学
CiteScore
8.10
自引率
4.40%
发文量
511
审稿时长
1.3 months
期刊介绍: With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.
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