Oxygen-Releasing Hydrogels in Biomedicine: Present and Future

IF 6.4 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Materials Technologies Pub Date : 2025-06-12 DOI:10.1002/admt.202500362

Yongrui Cai, Can Zhou, Zichuan Ding, Jiaxuan Fan, Yahao Lai, Chao Huang, Boyi Jiang, Hongxiang Cai, Zongke Zhou, Zeyu Luo

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Abstract

Oxygen-releasing hydrogels (ORHs) have emerged as innovative biomedical platforms capable of delivering controlled oxygen through chemical, physical, or biological mechanisms, demonstrating significant potential in enhancing tissue regeneration, disease treatment, and biomedical engineering applications. Concurrently, their therapeutic performance and application scope are also shaped by fabrication strategies, with bulk hydrogel networks, electrospinning nanofibrous matrices, 3D bioprinted architectures, and transdermal microneedle systems each providing distinct spatiotemporal control over oxygen release profiles. Finally, ORHs effectively promote critical biological processes including cell proliferation, angiogenesis, and wound healing across dermal, cardiovascular, and neural systems. Overall, the development and application of ORHs represent a significant advancement in biomedicine with far-reaching implications for improving patient treatment outcomes. This review aims to explore the diverse uses and preparations of ORHs while highlighting their impact on biology and medicine.

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生物医学中的释氧水凝胶：现在与未来

氧释放水凝胶（ORHs）已经成为一种创新的生物医学平台，能够通过化学、物理或生物机制提供可控的氧气，在增强组织再生、疾病治疗和生物医学工程应用方面显示出巨大的潜力。同时，它们的治疗性能和应用范围也受到制造策略的影响，大块水凝胶网络、静电纺丝纳米纤维基质、3D生物打印架构和透皮微针系统都提供了对氧气释放谱的不同时空控制。最后，ORHs有效地促进皮肤、心血管和神经系统的关键生物过程，包括细胞增殖、血管生成和伤口愈合。总体而言，ORHs的开发和应用代表了生物医学的重大进步，对改善患者的治疗效果具有深远的意义。本文旨在探讨中药的多种用途和制备方法，并重点介绍其在生物学和医学上的影响。

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来源期刊

Advanced Materials Technologies Materials Science-General Materials Science

CiteScore

10.20

自引率

4.40%

发文量

566

期刊介绍： Advanced Materials Technologies Advanced Materials Technologies is the new home for all technology-related materials applications research, with particular focus on advanced device design, fabrication and integration, as well as new technologies based on novel materials. It bridges the gap between fundamental laboratory research and industry.