A ZnCl2-based pH-responsive low-melting mixture solvent for extracting psoralen from Ficus carica L. leaves: Insights from experimental and mechanism investigation

IF 3.9 3区 工程技术 Q2 ENGINEERING, CHEMICAL
Mengfei Tian , Mengying Zhang , Kuiwang Chen , Jie Liu , Jiahui Gong , Wenxue Sun , Chunying Li , Chunjian Zhao
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Abstract

Ficus carica L. is one of the most ancient fruit crops which is being cultivated in sub-tropical regions worldwide. Ficus carica L. leaves, which are considered agricultural by-products, are frequently discarded, leading to the wastage of biological resources. However, Ficus carica L. leaves are valuable source of psoralen (PSO) that displays multiple bioactive properties beneficial for the treatment of osteoporosis, viruses, bacteria, and inflammation. Therefore, enhancing the efficient isolation of PSO from Ficus carica L. leaves using sustainable solvents has been a focus. In this study, a switchable ZnCl2-based pH-responsive low-melting mixture solvent (LoMMS-ZnCl2) for sustainable extraction of PSO from Ficus carica L. leaves was developed. The LoMMS-ZnCl2 system, consisting of ZnCl2, DL-menthol, and octanoic acid (OA), demonstrates exceptional performance with an extraction yield of 30.68 mg·g−1 for PSO. After removing ZnCl2 from the LoMMS-ZnCl2 system using reverse extraction, the polarity of LoMMS was changed rapidly by pH stimulus, resulting in in-situ separation and enrichment of PSO. The extraction mechanism was further investigated by DFT simulation and nuclear magnetic resonance analysis, revealing that hydrogen bonding, halogen bonding, coordination bonding, and Van der Waals forces are the primary intermolecular interactions between LoMMS-ZnCl2 and PSO. This strategy highlights the potential of LoMMS-ZnCl2 for efficient and sustainable extraction of PSO from Ficus carica L. leaves. Furthermore, it also offers a valuable reference for utilizing LoMMS-ZnCl2 in the extraction of natural bioactive compounds from various plant materials.
基于zncl2的ph响应型低熔点混合溶剂提取无花果叶片补骨脂素的实验及机理研究
无花果(Ficus carica L.)是世界上亚热带地区最古老的水果作物之一。Ficus carica L.叶片被认为是农业副产品,经常被丢弃,导致生物资源浪费。然而,榕叶是补骨脂素(PSO)的宝贵来源,显示出多种生物活性特性,有利于治疗骨质疏松症、病毒、细菌和炎症。因此,利用可持续溶剂提高从无花果叶片中分离PSO的效率一直是研究的热点。本研究开发了一种可切换的zncl2 - ph响应型低熔点混合溶剂(LoMMS-ZnCl2),用于无花果叶片中PSO的可持续提取。由ZnCl2、dl -薄荷醇和辛酸(OA)组成的LoMMS-ZnCl2体系对PSO的提取率达到30.68 mg·g−1。用反萃取法从LoMMS-ZnCl2体系中去除ZnCl2后,在pH刺激下LoMMS极性迅速改变,导致PSO的原位分离富集。通过DFT模拟和核磁共振分析进一步研究了萃取机理,发现氢键、卤素键、配位键和范德华力是LoMMS-ZnCl2与PSO之间主要的分子间相互作用。该策略突出了LoMMS-ZnCl2在有效和可持续地从无花果叶片中提取PSO的潜力。同时也为LoMMS-ZnCl2在各种植物材料中天然生物活性物质的提取提供了有价值的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Engineering Research & Design
Chemical Engineering Research & Design 工程技术-工程:化工
CiteScore
6.10
自引率
7.70%
发文量
623
审稿时长
42 days
期刊介绍: ChERD aims to be the principal international journal for publication of high quality, original papers in chemical engineering. Papers showing how research results can be used in chemical engineering design, and accounts of experimental or theoretical research work bringing new perspectives to established principles, highlighting unsolved problems or indicating directions for future research, are particularly welcome. Contributions that deal with new developments in plant or processes and that can be given quantitative expression are encouraged. The journal is especially interested in papers that extend the boundaries of traditional chemical engineering.
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