Investigations on CRC tissue mimicking materials through radiological parameters

IF 1.4 3区物理与天体物理 Q3 INSTRUMENTS & INSTRUMENTATION

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms Pub Date : 2025-09-17 DOI:10.1016/j.nimb.2025.165842

Simranpreet Kaur , Amandeep Sharma

{"title":"Investigations on CRC tissue mimicking materials through radiological parameters","authors":"Simranpreet Kaur , Amandeep Sharma","doi":"10.1016/j.nimb.2025.165842","DOIUrl":null,"url":null,"abstract":"<div><div>The study analyse the suitability of different materials, equivalents to colorectal cancer (CRC) tissue, for accurate selection of phantom composition which is crucial for advanced treatment planning. The charged particle based therapies, contributes enhanced targeting due to Bragg peak effect, result in precise dose delivery with minimum damage to healthy tissues. On the other hand gamma ray based therapies are useful to treat deep and metastatic tumours. The simulation tools like SRIM, PAGEX and Phy-X are used to examine CRC tissue equivalent materials through radiological parameters i.e. Stopping Power, Range and Effective atomic number (Z<sub>eff</sub>) for charged particle ion beams (protons, alpha particles and carbon ions) in addition to Mass Absorption Coefficient (MAC), Computed Tomography (CT) Number and Z<sub>eff</sub> for gamma photons. The comparison of results obtained from recently developed database (PAGEX) with established ones (SRIM) confirm reliability of alternative tools, with maximum relative difference of ∼ 1 % for computed results, to analyse new phantom materials through a user-friendly approach. A transparent, durable and biocompatible material namely Celluloid (C<sub>6</sub>H<sub>8</sub>N<sub>2</sub>O<sub>9</sub>) having mass density 1.45 g/cm<sup>3</sup> is found to closely mimic CRC tissue characteristics for different ion beams as well as gamma photons, thus found to be best phantom composition for trials of medical applications. The work emphasizes on the significance of best tissue equivalent materials for optimizing different radiation therapies, upgrading treatment outcomes and eventually increasing patient survival with quality of life.</div></div>","PeriodicalId":19380,"journal":{"name":"Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms","volume":"568 ","pages":"Article 165842"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168583X25002320","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}

引用次数: 0

Abstract

The study analyse the suitability of different materials, equivalents to colorectal cancer (CRC) tissue, for accurate selection of phantom composition which is crucial for advanced treatment planning. The charged particle based therapies, contributes enhanced targeting due to Bragg peak effect, result in precise dose delivery with minimum damage to healthy tissues. On the other hand gamma ray based therapies are useful to treat deep and metastatic tumours. The simulation tools like SRIM, PAGEX and Phy-X are used to examine CRC tissue equivalent materials through radiological parameters i.e. Stopping Power, Range and Effective atomic number (Z_eff) for charged particle ion beams (protons, alpha particles and carbon ions) in addition to Mass Absorption Coefficient (MAC), Computed Tomography (CT) Number and Z_eff for gamma photons. The comparison of results obtained from recently developed database (PAGEX) with established ones (SRIM) confirm reliability of alternative tools, with maximum relative difference of ∼ 1 % for computed results, to analyse new phantom materials through a user-friendly approach. A transparent, durable and biocompatible material namely Celluloid (C₆H₈N₂O₉) having mass density 1.45 g/cm³ is found to closely mimic CRC tissue characteristics for different ion beams as well as gamma photons, thus found to be best phantom composition for trials of medical applications. The work emphasizes on the significance of best tissue equivalent materials for optimizing different radiation therapies, upgrading treatment outcomes and eventually increasing patient survival with quality of life.

查看原文本刊更多论文

利用放射学参数研究结直肠癌组织模拟材料

该研究分析了不同材料的适用性，相当于结直肠癌（CRC）组织，以准确选择幻体成分，这对后期治疗计划至关重要。基于带电粒子的治疗，由于布拉格峰效应，有助于增强靶向性，导致精确的剂量递送，对健康组织的损伤最小。另一方面，基于伽马射线的疗法对治疗深部和转移性肿瘤是有用的。模拟工具如SRIM， PAGEX和Phy-X被用来检查CRC组织等效材料通过放射学参数，即停止功率，范围和有效原子序数（Zeff）带电粒子离子束（质子，α粒子和碳离子）除了质量吸收系数（MAC），计算机断层扫描（CT）数和Zeff伽玛光子。从最近开发的数据库（PAGEX）获得的结果与已建立的数据库（SRIM）的结果进行比较，确认了替代工具的可靠性，计算结果的最大相对差异为~ 1%，通过用户友好的方法分析新的幽灵材料。一种透明、耐用和具有生物相容性的材料，即赛璐珞（C6H8N2O9），其质量密度为1.45 g/cm3，可以非常接近地模拟不同离子束和伽马光子下CRC组织的特征，因此被认为是用于医疗应用试验的最佳幻影成分。这项工作强调了最佳组织等效材料在优化不同放射治疗、提高治疗效果和最终提高患者生存和生活质量方面的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms 物理-核科学技术

CiteScore

2.80

自引率

7.70%

发文量

231

审稿时长

1.9 months

期刊介绍： Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.