Acute exacerbation of interstitial lung disease in a patient with chronic inflammatory demyelinating polyradiculoneuropathy: A case report

IF 0.7 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI:10.1016/j.rmcr.2025.102295

Koharu Harada , Takunori Ogawa , Ryosuke Nagaoka, Akihiko Kawana, Yoshifumi Kimizuka

{"title":"Acute exacerbation of interstitial lung disease in a patient with chronic inflammatory demyelinating polyradiculoneuropathy: A case report","authors":"Koharu Harada , Takunori Ogawa , Ryosuke Nagaoka, Akihiko Kawana, Yoshifumi Kimizuka","doi":"10.1016/j.rmcr.2025.102295","DOIUrl":null,"url":null,"abstract":"<div><div>Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune neuropathy, and its association with interstitial lung disease (ILD) is extremely uncommon. Herein, we report the case of a 65-year-old woman with a long-standing history of CIDP who presented with simultaneous relapse of CIDP and acute exacerbation of ILD. The ILD exacerbation was resistant to high-dose corticosteroids, with worsening respiratory symptoms and progressive ground-glass opacities on imaging. Intravenous immunoglobulin (IVIG), administered 10 days after steroid initiation, resulted in significant clinical and radiological improvement in both ILD and neuropathy. This is the first reported case of acute exacerbation of CIDP-related ILD successfully treated with IVIG, which suggests a potential relationship between CIDP and ILD and suggests that IVIG may be a viable therapeutic option for steroid-resistant ILD exacerbations in patients with CIDP.</div></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":"58 ","pages":"Article 102295"},"PeriodicalIF":0.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Medicine Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213007125001315","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune neuropathy, and its association with interstitial lung disease (ILD) is extremely uncommon. Herein, we report the case of a 65-year-old woman with a long-standing history of CIDP who presented with simultaneous relapse of CIDP and acute exacerbation of ILD. The ILD exacerbation was resistant to high-dose corticosteroids, with worsening respiratory symptoms and progressive ground-glass opacities on imaging. Intravenous immunoglobulin (IVIG), administered 10 days after steroid initiation, resulted in significant clinical and radiological improvement in both ILD and neuropathy. This is the first reported case of acute exacerbation of CIDP-related ILD successfully treated with IVIG, which suggests a potential relationship between CIDP and ILD and suggests that IVIG may be a viable therapeutic option for steroid-resistant ILD exacerbations in patients with CIDP.

查看原文本刊更多论文

慢性炎症性脱髓鞘性多神经根神经病患者间质性肺病急性加重1例报告

慢性炎症性脱髓鞘性多根神经病变（CIDP）是一种罕见的自身免疫性神经病变，其与间质性肺疾病（ILD）的关联极为罕见。在此，我们报告一位65岁的女性，她有长期的CIDP病史，同时出现CIDP复发和ILD急性加重。ILD恶化对大剂量皮质类固醇具有耐药性，呼吸系统症状恶化，影像学上出现进行性毛玻璃样混浊。静脉注射免疫球蛋白（IVIG），在类固醇开始治疗10天后，导致ILD和神经病变的临床和放射学显著改善。这是首次报道的IVIG成功治疗CIDP相关ILD急性加重的病例，这表明CIDP和ILD之间存在潜在的关系，并表明IVIG可能是CIDP患者类固醇抵抗性ILD加重的可行治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊