Nano sense-TFET: HJ-DGVTFET based salivary and serum CerbB-2 biomarker detection for breast cancer

Abstract

Breast cancer is a prevalent and potentially life-threatening disease, emphasizing the importance of early detection and monitoring. A key target for the identification of diagnostic bioanalytes is the CerbB-2 bioanalyte (BA), whose overexpression has been linked to aggressive types of breast cancer. In this study, a highly sensitive biosensor based on an In_1−xGa_xAs/InP heterojunction Dual Gate Vertical tunnel FET (HJ-DGVTFET) is used to detect the breast cancer bioanalyte, CerbB-2, electrically in serum or saliva. In this work, interface charge modulation effect in HJ-DGVTFETs with integrated nano compatibility biosensors is considered for reliable, precise, and fast recognition of antigens in body fluids using blood serum rather than saliva. The suggested biosensor has a double cavity etched under the double gate structure to immobilize bioanalyte. This enhances the bioanalyte influence on the source-channel tunnelling rate and the electrical parameters of the suggested biosensor. Device sensitivity has been examined for various CerbB-2 concentrations in blood and saliva environments. According to our research, an III-V In_1−xGa_xAs/InP hetero junction with mole fraction x factor of 0.47 increases the likelihood of tunnelling. It enhances gate control on channel to get a higher sensitivity and I_ON/I_OFF ratio.