Drug‑related problems and associated factors among hospitalized pediatric patients in a general hospital, Tigrai, northern Ethiopia: a cross-sectional study

Global pediatrics Pub Date : 2025-09-09 DOI:10.1016/j.gpeds.2025.100293

Gebretekle Gebremichael Hailesilase, Haylay Araya Gebrezgabiher, Abrahaley Mulu Kidane

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Abstract

Background

Drug-related problems (DRPs) are associated with increased risks of morbidities and mortalities. However, there are limited studies on DRPs among hospitalized pediatric patients in Ethiopia. This study aimed to evaluate DRPs and associated factors among hospitalized pediatric patients in Adigrat general hospital, Tigrai, northern Ethiopia.

Methods

A retrospective cross-sectional study was conducted among hospitalized pediatric patients in Adigrat general hospital. Data was collected from the patients’ medical charts between 01 July 2024 and 31 August 2024. Potential drug-drug interactions were screened using Micromedex 2.0 software. Logistic regression was used to analyze association of variables with DRPs. Data was analyzed using statistical package for social science version 21 and statistical significance was set at P value < 0.05 in the multivariate analysis.

Results

A total of 114 (77.6 %) patients had at least one DRP. A total of 325 DRPs were identified in those 114 patients, averaging 2.85 (1

-

13) DRPs per patient. Moreover, 15.0 % of the patients experienced

\geq

5 DRPs. Regarding the proportion of DRPs, unnecessary drug therapy, ADRs and dosage too low accounted for 22.8, 18.5 and 18.1 % of the DRPs, respectively. Substantial proportions (n = 47; 14.5 %) of the ADRs were due to potential drug-drug interactions. Anti-infectives for systemic use (68.8 %) and drugs of the alimentary tract and metabolism (10.2 %) were the most commonly implicated drug classes in DRPs. The number of diseases per patient was significantly associated with the occurrence of DRPs (Adjusted Odds ratio = 5.875, 95 % CI: 1.735–19.895).

Conclusions

The DRPs were prevalent among hospitalized pediatric patients. Unnecessary drug therapy, ADRs and dosage too low were the most widespread categories of DRPs. Clinicians should follow pediatrics guidelines and use drug interaction screening databases when prescribing drugs to pediatric patients.

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埃塞俄比亚北部提格拉伊一家综合医院住院儿科患者的药物相关问题及相关因素：一项横断面研究

背景：药物相关问题（DRPs）与发病率和死亡率的风险增加有关。然而，关于埃塞俄比亚住院儿科患者的drp的研究有限。本研究旨在评估埃塞俄比亚北部Tigrai Adigrat综合医院住院儿科患者的DRPs及其相关因素。方法对阿迪格拉总医院住院的儿科患者进行回顾性横断面研究。从2024年7月1日至2024年8月31日期间的患者病历中收集数据。使用Micromedex 2.0软件筛选潜在的药物-药物相互作用。采用Logistic回归分析变量与DRPs的相关性。数据分析采用social science version 21统计软件包，多因素分析采用P值<； 0.05进行统计学显著性分析。结果114例（77.6%）患者至少发生一次DRP。114例患者共发现325个DRPs，平均每位患者2.85（1−13）个DRPs。15.0%的患者出现≥5次drp。从DRPs的比例来看，药物治疗不必要、不良反应和剂量过低分别占DRPs的22.8%、18.5%和18.1%。相当大比例（n = 47; 14.5%）的不良反应是由于潜在的药物-药物相互作用。全身使用的抗感染药物（68.8%）和消化道和代谢药物（10.2%）是DRPs中最常见的涉及药物类别。每位患者的疾病数量与DRPs的发生显著相关（校正优势比= 5.875,95% CI: 1.735-19.895）。结论住院儿科患者普遍存在drp。不必要的药物治疗、不良反应和剂量过低是最常见的DRPs类别。临床医生在给儿科患者开处方时应遵循儿科指南并使用药物相互作用筛选数据库。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Global pediatrics Perinatology, Pediatrics and Child Health

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