{"title":"Smartphone-Colorimetric Biosensor for Uric Acid through Morphological Transition of Silver Nanoplates","authors":"Liangchong Yu, Xiaobing Gao, Xiaoya Liu, Xiaohan Li, Zhenhua Gu, Taolei Sun* and Guanbin Gao*, ","doi":"10.1021/acsanm.5c03428","DOIUrl":null,"url":null,"abstract":"<p >Elevated uric acid (UA) serves as a critical biomarker for hyperuricemia-related disorders, yet conventional detection faces cost and complexity limitations. Here, we developed an enzyme-free smartphone-colorimetric biosensor using silver triangular nanoplates (AgTNPs). These anisotropic nanostructures exhibit morphology-dependent surface plasmon resonance (SPR), enabling UA-selective etching that induces a blue-to-yellow color shift. Spectrophotometry revealed a linear response (40–110 μM, R<sup>2</sup> > 0.992) correlating with blue shifts. Smartphone-based green-channel analysis achieved comparable accuracy (R<sup>2</sup> = 0.98) in a 96-well plate. Transmission electron microscopy confirmed UA-driven morphological evolution from triangular to spherical nanoparticles via anisotropic etching. This dual-mode platform provides a cost-effective solution for point-of-care UA monitoring.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 37","pages":"17870–17875"},"PeriodicalIF":5.5000,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.5c03428","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Elevated uric acid (UA) serves as a critical biomarker for hyperuricemia-related disorders, yet conventional detection faces cost and complexity limitations. Here, we developed an enzyme-free smartphone-colorimetric biosensor using silver triangular nanoplates (AgTNPs). These anisotropic nanostructures exhibit morphology-dependent surface plasmon resonance (SPR), enabling UA-selective etching that induces a blue-to-yellow color shift. Spectrophotometry revealed a linear response (40–110 μM, R2 > 0.992) correlating with blue shifts. Smartphone-based green-channel analysis achieved comparable accuracy (R2 = 0.98) in a 96-well plate. Transmission electron microscopy confirmed UA-driven morphological evolution from triangular to spherical nanoparticles via anisotropic etching. This dual-mode platform provides a cost-effective solution for point-of-care UA monitoring.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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