Recent Advances in Catalytic Asymmetric Hydrogenation of β-Ketoesters

IF 3.5 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2025-08-27 DOI:10.1021/acs.oprd.5c00258

Xue Song, Qingsong Chen, Liuzeng Chen, Banfeng Ruan*, Bin Li* and Xingxing Zhang*,

引用次数: 0

Abstract

The catalytic asymmetric reduction of β-ketoesters represents a cornerstone transformation in modern organic synthesis, enabling the production of enantiomerically enriched β-hydroxyesters─critical building blocks in the synthesis of pharmaceuticals, vitamins, and natural products. This review highlights recent advances in the catalytic asymmetric reduction of β-ketoesters, with particular emphasis on the relationship between catalyst architecture and stereochemical outcomes. The discussion encompasses the evolving role of carriers in heterogeneous asymmetric catalysis, and the potential for industrial applications. Furthermore, this review also discussed the current technological limitations and emerging opportunities in the field, providing insights into future directions for research and development.

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β-酮酯催化不对称加氢研究进展

β-酮酯的催化不对称还原代表了现代有机合成的基石转变，使生产对映体富集的β-羟基酯成为可能，这是合成药物、维生素和天然产物的关键组成部分。本文综述了β-酮酯催化不对称还原的最新进展，特别强调了催化剂结构与立体化学结果之间的关系。讨论了载体在多相不对称催化中的作用，以及工业应用的潜力。此外，本文还讨论了该领域目前的技术限制和新兴机会，并对未来的研究和发展方向提出了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.