Association between Outdoor Daylight Exposure Duration and Primary Open-Angle Glaucoma.

IF 4.2 1区 医学 Q1 OPHTHALMOLOGY
Jianqi Chen,Shaofen Huang,Xiaohua Zhuo,Xuhao Chen,Rui Xie,Ruiyu Luo,Xinyue Shen,Yue Xiao,Jingying Liang,Yingting Zhu,Jingfeng Mu,Hongmei Tan,Yehong Zhuo
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引用次数: 0

Abstract

PURPOSE As a crucial environmental factor, outdoor daylight exposure has become an increasing focus in ophthalmic research. Although exploratory studies have indicated a potential connection between daylight exposure and primary open-angle glaucoma (POAG), a detailed association remains largely unknown. This study aimed to examine the association using data from the UK Biobank. DESIGN Combined cross-sectional and cohort study. PARTICIPANTS Following the application of exclusion criteria, 67,558 and 71,480 participants were included in the analysis of POAG incidence and prevalence, respectively. Additionally, 69,441 and 28,029 participants were included in the analysis of intraocular pressure (IOP) and ganglion cell complex (GCC) thickness, which are traits related to POAG. METHODS The initial assessment of outdoor daylight exposure duration was conducted using a standardized touchscreen questionnaire and measured in hours per day. Cox proportional hazard models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for each additional hour of exposure per day. Additionally, logistic regression models and linear regression models were utilized to investigate the association with POAG prevalence and POAG-related traits, with adjustments made for multiple covariates. MAIN OUTCOME MEASURES POAG incidence, prevalence, and related traits. RESULTS After adjusting for all covariates, annual average daylight exposure duration (HR, 1.10; 95% CI, 1.02-1.18; P = 0.009) and summer daylight exposure duration (HR, 1.08; 95% CI, 1.02-1.14; P = 0.009) were associated with an increased incidence of POAG, and stronger associations were observed for males. Participants with elevated outdoor exposure duration had higher IOP levels across annual exposure (β, 0.04, 95% CI, 0.03-0.06, P<0.001), summer exposure (β, 0.04, 95% CI, 0.03-0.05, P<0.001), and winter exposure (β = 0.02, 95% CI, 0.01-0.04, P=0.007). No association was found between outdoor daylight exposure and the prevalence of POAG or GCC thickness. CONCLUSIONS Prolonged daylight exposure, particularly during the summer, is associated with an elevated risk of POAG incidence, possibly due to increased IOP. These findings highlight the need for protective strategies against excessive daylight exposure.
室外日光照射时间与原发性开角型青光眼的关系
摘要户外日光照射作为一个重要的环境因素,已成为眼科研究的热点。尽管探索性研究表明日光暴露与原发性开角型青光眼(POAG)之间存在潜在联系,但详细的关联在很大程度上仍然未知。这项研究的目的是利用英国生物银行的数据来检验这种联系。设计结合横断面和队列研究。根据排除标准,67,558名和71,480名参与者分别被纳入POAG发病率和患病率分析。此外,69,441和28,029名参与者被纳入了与POAG相关的特征眼内压(IOP)和神经节细胞复合体(GCC)厚度的分析。方法采用标准化触屏问卷对室外日光暴露时间进行初步评估,测量单位为每天小时数。采用Cox比例风险模型估计每天每增加1小时暴露的风险比(hr)和95%置信区间(ci)。此外,利用logistic回归模型和线性回归模型对POAG患病率和POAG相关性状进行相关性研究,并对多个协变量进行调整。主要观察指标:oag的发生率、患病率及相关特征。结果在调整所有协变量后,年平均日照时间(HR, 1.10; 95% CI, 1.02-1.18; P = 0.009)和夏季日照时间(HR, 1.08; 95% CI, 1.02-1.14; P = 0.009)与POAG发病率增加相关,且在男性中观察到更强的相关性。户外暴露时间延长的参与者在年度暴露(β, 0.04, 95% CI, 0.03-0.06, P<0.001),夏季暴露(β, 0.04, 95% CI, 0.03-0.05, P<0.001)和冬季暴露(β = 0.02,95% CI, 0.01-0.04, P=0.007)中IOP水平较高。室外日光暴露与POAG或GCC厚度患病率之间没有关联。结论:长时间的日光照射,特别是在夏季,与POAG发病率升高有关,可能是由于IOP升高。这些发现强调了防止过度日光照射的保护策略的必要性。
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来源期刊
CiteScore
9.20
自引率
7.10%
发文量
406
审稿时长
36 days
期刊介绍: The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.
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