Effect of Ocular Magnification Correction on Measurements of Macula Ganglion Cell Complex in Myopic Children.

IF 4.2 1区 医学 Q1 OPHTHALMOLOGY
Rachel S Chong,Bryan Sim,Hla Myint Htoon,Audrey Chia
{"title":"Effect of Ocular Magnification Correction on Measurements of Macula Ganglion Cell Complex in Myopic Children.","authors":"Rachel S Chong,Bryan Sim,Hla Myint Htoon,Audrey Chia","doi":"10.1016/j.ajo.2025.09.019","DOIUrl":null,"url":null,"abstract":"PURPOSE\r\nOptical Coherence Tomography (OCT) imaging in myopic eyes may be influenced by measurement error from axial length-induced magnification effects. We studied the effects of magnification correction on ganglion cell complex (GCL++) thickness in myopic children.\r\n\r\nDESIGN\r\nClinical cohort SUBJECTS: Children aged 7-16 years in a myopic clinic METHODS: Data collected included age, gender, race, cycloplegic refraction, axial length (AL), keratometry (K), intraocular pressure (IOP), cup-to-disc ratio (CDR), optic disc tilt, peripapillary atrophy (PPA) and OCT macula scans from the right eye. GCL++ thickness in the central, inner and outer superior, inferior, nasal and temporal quadrants was measured with or without adjustments for ocular magnification using the Littmann-Bennett formula.\r\n\r\nRESULTS\r\n492 subjects, comprising 46.7% male and 91.8% Chinese with an average age of 10.3±1.6 years were included in the study. Mean spherical equivalent (SE) was -4.43±2.24D, and AL was 25.04±1.05 mm. Multivariate analysis showed unadjusted and adjusted GCL++ thickening in older age; in the central and inner quadrants in males; and in the outer temporal quadrant in Chinese children. Central unadjusted and adjusted GCL++ were also thicker with decreased SE, flatter K and increased AL. In other quadrants, unadjusted GCL++ was thinner with decreasing SE and increasing AL in all but the nasal quadrant. Adjusted values were thicker with decreased SE, flatter K, and increasing AL (p≤0.001 for all). IOP, CDR, optic disc tilt, PPA and myopia treatment had no effect on GCL++.\r\n\r\nDISCUSSION\r\nOcular magnification correction of OCT-measured retinal layer thickness using adjustments for axial length suggests increasing myopia is associated with thickening of the ganglion cell complex in children.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"38 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajo.2025.09.019","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

PURPOSE Optical Coherence Tomography (OCT) imaging in myopic eyes may be influenced by measurement error from axial length-induced magnification effects. We studied the effects of magnification correction on ganglion cell complex (GCL++) thickness in myopic children. DESIGN Clinical cohort SUBJECTS: Children aged 7-16 years in a myopic clinic METHODS: Data collected included age, gender, race, cycloplegic refraction, axial length (AL), keratometry (K), intraocular pressure (IOP), cup-to-disc ratio (CDR), optic disc tilt, peripapillary atrophy (PPA) and OCT macula scans from the right eye. GCL++ thickness in the central, inner and outer superior, inferior, nasal and temporal quadrants was measured with or without adjustments for ocular magnification using the Littmann-Bennett formula. RESULTS 492 subjects, comprising 46.7% male and 91.8% Chinese with an average age of 10.3±1.6 years were included in the study. Mean spherical equivalent (SE) was -4.43±2.24D, and AL was 25.04±1.05 mm. Multivariate analysis showed unadjusted and adjusted GCL++ thickening in older age; in the central and inner quadrants in males; and in the outer temporal quadrant in Chinese children. Central unadjusted and adjusted GCL++ were also thicker with decreased SE, flatter K and increased AL. In other quadrants, unadjusted GCL++ was thinner with decreasing SE and increasing AL in all but the nasal quadrant. Adjusted values were thicker with decreased SE, flatter K, and increasing AL (p≤0.001 for all). IOP, CDR, optic disc tilt, PPA and myopia treatment had no effect on GCL++. DISCUSSION Ocular magnification correction of OCT-measured retinal layer thickness using adjustments for axial length suggests increasing myopia is associated with thickening of the ganglion cell complex in children.
眼部放大矫正对近视儿童黄斑神经节细胞复合体测量的影响。
目的光学相干断层扫描(OCT)在近视眼成像中可能受到轴向长度引起的放大效应的测量误差的影响。我们研究了放大矫正对近视儿童神经节细胞复合体(GCL++)厚度的影响。方法:收集的数据包括年龄、性别、种族、单眼麻痹屈光、眼轴长(AL)、角膜度数(K)、眼内压(IOP)、杯盘比(CDR)、视盘倾斜、乳头周围萎缩(PPA)和右眼OCT黄斑扫描。使用Littmann-Bennett公式测量中央、内外上、下、鼻和颞象限的GCL++厚度,调整或不调整眼部放大率。结果共纳入492例受试者,男性46.7%,华人91.8%,平均年龄10.3±1.6岁。平均球面等效(SE)为-4.43±2.24D, AL为25.04±1.05 mm。多因素分析显示,未调整和调整后的GCL++在老年人中增厚;在雄性的中心和内象限;在中国儿童的颞外象限。中央未调整和调整的GCL++也随着SE的降低、K的平坦和AL的增加而变厚。在其他象限中,除鼻部象限外,未调整的GCL++随SE的降低和AL的增加而变薄。调整后的值随着SE的降低、K的平坦和AL的增加而变厚(p≤0.001)。眼压、CDR、视盘倾斜、PPA和近视治疗对gcl++无影响。使用轴向长度调整oct测量视网膜层厚度的眼部放大校正表明,儿童近视增加与神经节细胞复合体增厚有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
9.20
自引率
7.10%
发文量
406
审稿时长
36 days
期刊介绍: The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信