An Epigenetic Perspective of Gene Expression: The Regulatory Tools.

IF 1.6 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2025059334

Abigail Person, Andrew J Fritz, Emory Pacht, Rabail H Toor, Rahim Ullah, Janine S Warren, Bodhisattwa Banerjee, Jackson R Del Porto, Sadie J Korzec, Genevieve Brzoza, Lukas B Lipps, Jessica L Heath, Prachi N Ghule, Johnathan A R Gordon, Andre J van Wijnen, Jane B Lian, Janet L Stein, Gary S Stein

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引用次数: 0

Abstract

Epigenetic control synergizes with DNA encoded regulatory information to provide a blueprint for gene expression that supports biological processes including phenotype, proliferation, growth control, metabolic regulation, cell survival, and immune function. Epigenetic regulation, non-DNA encoded regulatory information, mediates the selective expression and suppression of transcription in a phenotypically responsive manner. Parameters of epigenetic control are post-translational histone modifications, DNA methylation, mitotic gene bookmarking, nucleosome structure, and higher order chromatin organization. Epigenetically compromised gene expression is functionally linked to the onset and progression of diseases that include cancer. Epigenetic targeting strategies have the potential for cancer therapy with enhanced specificity and reduced off-target consequences.

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基因表达的表观遗传学视角：调控工具。

表观遗传控制与DNA编码的调控信息协同作用，为支持生物学过程的基因表达提供蓝图，包括表型、增殖、生长控制、代谢调节、细胞存活和免疫功能。表观遗传调控是一种非dna编码的调控信息，以表型响应的方式介导选择性表达和转录抑制。表观遗传控制的参数包括翻译后组蛋白修饰、DNA甲基化、有丝分裂基因书签、核小体结构和高阶染色质组织。表观遗传受损的基因表达在功能上与包括癌症在内的疾病的发生和进展有关。表观遗传靶向策略具有增强特异性和减少脱靶后果的癌症治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.