Development of the semicircular canals and otolithic organs of the vertebrate inner ear.

2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-05-22 DOI:10.1016/bs.ctdb.2025.04.001
Tanya T Whitfield
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引用次数: 0

Abstract

The vestibular apparatus of the inner ear functions to sense gravity and motion. Working together with the visual and proprioceptive systems via various muscular reflexes, it enables an organism to stabilise head position, gaze and body posture, both at rest and during movement. These functions are dependent on sensory hair cells that respond to mechanical stimulation, together with their associated non-sensory structures, including fluid-filled ducts and chambers, specialised extracellular matrices, and biomineralised crystalline deposits. The focus of this review is on the embryonic development of selected elements of the vestibular system: morphogenesis of the semicircular canal ducts, development of the ampullae and sensory cristae, and formation of the biomineralised otoliths and otoconia. Recent findings have identified new genetic players, dynamic cross-repressive gene regulatory networks, and morphogenetic mechanisms that act to shape the developing vestibular system. A final section of the review highlights approaches that link developmental genetic studies to an understanding of cell and tissue mechanics, vestibular-driven behaviour, evolution and human disease.

脊椎动物内耳的半规管和耳石器官的发育。
内耳的前庭器官的功能是感觉重力和运动。它通过各种肌肉反射与视觉和本体感觉系统协同工作,使生物体在休息和运动时都能稳定头部位置、凝视和身体姿势。这些功能依赖于对机械刺激有反应的感觉毛细胞,以及它们相关的非感觉结构,包括充满液体的导管和腔室、专门的细胞外基质和生物矿化结晶沉积物。本综述的重点是前庭系统的胚胎发育:半圆形管的形态发生,壶腹和感觉嵴的发育,以及生物矿化耳石和耳郭的形成。最近的发现已经确定了新的遗传参与者,动态交叉抑制基因调控网络,以及形成发展中的前庭系统的形态发生机制。综述的最后一部分强调了将发育遗传学研究与细胞和组织力学、前庭驱动行为、进化和人类疾病的理解联系起来的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
0.00%
发文量
91
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