Adolescent-onset primary brain calcification: a case report presenting with neuropsychiatric symptoms.

IF 0.5 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI:10.1080/13554794.2025.2562920

Yiğit Özaydın, Fevzi Tuna Ocakoğlu, Eyüp Sabri Ercan

引用次数: 0

Abstract

Fahr syndrome is a rare neurological condition characterized by idiopathic bilateral basal ganglia calcifications. It often presents psychiatric symptoms that may precede neurological signs, especially in adolescents, making early diagnosis a challenge. We report the case of a 17-year-old male who exhibited treatment-resistant psychotic symptoms including aggression, paranoia, and auditory hallucinations beginning at age 12. Extensive bilateral calcifications in the basal ganglia and subcortical regions were identified via cranial CT, with no evidence of metabolic or infectious etiology, confirming the diagnosis of idiopathic Fahr syndrome. Treatment with clozapine and brexpiprazole led to rapid and sustained symptom remission. This case emphasizes the importance of neuroimaging in adolescents with atypical psychiatric presentations and suggests that combined antipsychotic therapy may be effective in managing Fahr syndrome-related psychosis.

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青少年发病的原发性脑钙化：1例报告，表现为神经精神症状。

Fahr综合征是一种罕见的以特发性双侧基底神经节钙化为特征的神经系统疾病。它通常表现出精神症状，可能先于神经症状，特别是在青少年中，这使得早期诊断成为一项挑战。我们报告一名17岁男性的病例，他在12岁时表现出抵抗治疗的精神病症状，包括攻击，偏执和幻听。颅脑CT发现双侧基底节区和皮质下区广泛钙化，无代谢性或感染性病因，证实特发性Fahr综合征的诊断。氯氮平和布雷哌唑治疗导致快速和持续的症状缓解。本病例强调了神经影像学对具有非典型精神表现的青少年的重要性，并提示联合抗精神病药物治疗可能对Fahr综合征相关精神病的治疗有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.