Comparison of different methods to image the tear film before and during contact lens wear.

IF 3.7 3区 医学 Q1 OPHTHALMOLOGY
Srikanth Dumpati, Mukesh Kumar, Ajay Kumar Vijay, Jacqueline Tan, Mark Willcox
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Abstract

Purpose: To evaluate the repeatability and compare non-invasive tear breakup time (NIBUT) and tear film lipid layer thickness (TFLLT) measurements obtained using subjective (Keeler Tearscope-Plus) and objective (Oculus Keratograph 5M and LipiView II Interferometer) instruments before and during soft contact lens (CL) wear.

Methods: This prospective, randomised, double-masked, crossover study involved ten healthy participants who wore two types of daily disposable soft CLs: hydrogel and silicone hydrogel. NIBUT and TFLLT were assessed under pre cornea (before lens insertion) and pre lens (over the lens) conditions. NIBUT was measured using Tearscope-Plus and the Oculus Keratograph 5M, while TFLLT was assessed with Tearscope-Plus and the LifpiView II Interferometer. Repeatability was evaluated using repeated-measures ANOVA within-subject standard deviation (Sw), coefficient of repeatability (CR), and intraclass correlation coefficient (ICC). Correlation between instruments was assessed using Spearman coefficients, while agreement was evaluated using Bland-Altman analysis.

Results: NIBUT measured with the Tearscope-Plus demonstrated good to excellent repeatability (ICC: 0.84-0.96). TFLLT measured with the LipiView II Interferometer showed excellent repeatability (ICC: 0.92-0.96). The Oculus Keratograph 5M showed moderate to good repeatability for NIBUT (ICC: 0.67-0.85). No significant correlations were observed between NIBUT measurements from the Tearscope-Plus and Oculus Keratograph 5M (r range: 0.02-0.30; p > 0.05). In contrast, strong correlations were observed between TFLLT measurements from the Tearscope-Plus and LipiView II Interferometer in pre cornea (r = 0.72, p < 0.01) and pre hydrogel (r = 0.74, p = 0.02) conditions, with a moderate, non-significant correlation in the pre silicone hydrogel condition (r = 0.51, p = 0.13). Bland-Altman analysis revealed wide limits of agreement between instruments, indicating substantial measurements variability.

Conclusion: Tearscope-Plus and LipiView II Interferometer demonstrated high repeatability for NIBUT and TFLLT, respectively. However, the Tearscope-Plus overestimated both NIBUT and TFLLT values compared to objective instruments, indicating that these instruments should not be used interchangeably in clinical practice or research.

隐形眼镜佩戴前后泪膜成像方法的比较。
目的:评价软性隐形眼镜(CL)佩戴前和佩戴期间使用主观(Keeler Tearscope-Plus)和客观(Oculus Keratograph 5M和LipiView II干涉仪)仪器测量的无创撕裂时间(NIBUT)和泪膜脂质层厚度(TFLLT)的可重复性,并进行比较。方法:这项前瞻性、随机、双盲、交叉研究纳入了10名健康参与者,他们使用两种类型的日常一次性软cl:水凝胶和硅水凝胶。在角膜前(植入晶状体之前)和晶状体前(超过晶状体)条件下评估NIBUT和TFLLT。使用Tearscope-Plus和Oculus角膜摄影仪5M测量NIBUT,而使用Tearscope-Plus和LifpiView II干涉仪评估TFLLT。使用重复测量方差分析(repeated-measures ANOVA)评估受试者内标准差(Sw)、可重复性系数(CR)和类内相关系数(ICC)。使用Spearman系数评估仪器之间的相关性,而使用Bland-Altman分析评估一致性。结果:用Tearscope-Plus测量NIBUT具有良好的重复性(ICC: 0.84-0.96)。LipiView II干涉仪测量的TFLLT具有良好的重复性(ICC: 0.92-0.96)。Oculus Keratograph 5M对NIBUT显示中等至良好的重复性(ICC: 0.67-0.85)。Tearscope-Plus和Oculus Keratograph 5M的NIBUT测量值之间无显著相关性(r范围:0.02-0.30;p < 0.05)。相比之下,Tearscope-Plus和LipiView II干涉仪在角膜前的TFLLT测量结果之间存在很强的相关性(r = 0.72, p)。结论:Tearscope-Plus和LipiView II干涉仪分别具有高重复性。然而,与客观仪器相比,Tearscope-Plus高估了NIBUT和TFLLT值,这表明这些仪器不应在临床实践或研究中互换使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.60
自引率
18.80%
发文量
198
审稿时长
55 days
期刊介绍: Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.
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