Increased use of psychiatric medication following incident celiac autoimmunity

IF 3.3 2区 医学 Q2 PSYCHIATRY
Quinn Goddard , Gilaad G. Kaplan , Stephanie Coward , Tyler Williamson , Scott Patten , Marcia Bruce , Jenny Godley , Rita Henderson , Tara A. Whitten , Araba Chintoh , James A. King
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引用次数: 0

Abstract

Background

Celiac disease is associated with an increased risk of psychiatric disorders, yet little is known about formal treatment for such conditions among patients.

Methods

Using administrative healthcare data, we conducted a population-based cohort study of individuals newly positive for celiac autoimmunity (tTG) between 2015 and 2023 in Alberta, Canada. Individuals were linked to medication dispensations to assess use of antidepressants, anxiolytics, and antipsychotics. We calculated the proportion of days covered (PDC) by psychiatric medication as the number of days for which medication was prescribed. We conducted identical sub-analyses for individuals with anxiety and/or depression-related healthcare encounters prior to their positive tTG test.

Results

Among 14,323 newly tTG-positive individuals, a greater proportion dispensed antidepressants (22.5 % vs 27.6 %) and antipsychotics (4.6 % vs 6.0 %) post-tTG, while a lower proportion dispensed anxiolytics post-tTG (15.4 % vs 11.4 %), all p < 0.001. We observed higher odds of being dispensed psychiatric medication post-tTG (OR = 1.22; 95 % CI = 1.14, 1.31). Median PDC also significantly increased post-tTG test for antidepressants (2.8 % vs 21.1 %) and antipsychotics (0.4 % vs 6.3 %), p < 0.001. However, a decreased odds of medication dispensation (OR = 0.42; 95 % CI: 0.32, 0.56) and median PDC post-tTG (45.1 % vs. 10.1 %, p < 0.001) were observed among those with a previous depression/anxiety-related healthcare encounter.

Conclusion

These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG positivity.
乳糜泻自身免疫事件后精神病药物的使用增加。
背景:乳糜泻与精神疾病风险增加有关,但对此类患者的正式治疗知之甚少。方法:利用行政卫生保健数据,我们对加拿大阿尔伯塔省2015年至2023年间乳糜泻自身免疫(tTG)新阳性个体进行了一项基于人群的队列研究。个体与药物分配相关联,以评估抗抑郁药,抗焦虑药和抗精神病药的使用。我们计算了精神病药物覆盖天数的比例(PDC)作为处方药物的天数。我们对tTG检测呈阳性之前有焦虑和/或抑郁相关医疗经历的个体进行了相同的亚分析。结果:14323例新发ttg阳性患者中,ttg后配用抗抑郁药(22.5%比27.6%)和抗精神病药(4.6%比6.0%)的比例较高,ttg后配用抗焦虑药的比例较低(15.4%比11.4%),均p < 0.05。这些发现强调有必要增加对乳糜泻人群精神合并症的筛查和/或监测,并进一步调查tTG阳性后更多使用精神药物的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Psychosomatic Research
Journal of Psychosomatic Research 医学-精神病学
CiteScore
7.40
自引率
6.40%
发文量
314
审稿时长
6.2 weeks
期刊介绍: The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.
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