Development of antibacterial coatings for endotracheal tubes with enhanced antibacterial release properties through combined antibiotic loading.

IF 3.2 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmacy and Pharmacology Pub Date : 2025-09-14 DOI:10.1093/jpp/rgaf078

Matthew P Wylie, Jia Li, Grainne Murphy, Jasmine Ross, Jane Burns, David S Jones, Colin P McCoy

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引用次数: 0

Abstract

Background: Ventilator-associated pneumonia (VAP) is a significant cause of patient morbidity and mortality worldwide. This study describes a strategy to develop antibacterial hydrogel-based coating for endotracheal tubes, composed of 2-hydroxyethyl methacrylate and methacrylic acid, capable of simultaneously delivering a combination of antibacterial agents to mitigate VAP.

Methods: Copolymer hydrogels were loaded with gentamicin, levofloxacin, and benzalkonium chloride (BAK), and their drug release profiles, antibacterial activity, and duration were determined.

Key findings: More than 95% and 99.99% reduction of bacterial adherence was observed for all the antibiotic-containing hydrogels after 4 and 24 h, respectively. Hydrogels loaded with BAK provided protection against Staphylococcus aureus for more than 30 days and hydrogels loaded with levofloxacin exhibited more than 10 days of persistence against Pseudomonas aeruginosa. Dual loading of levofloxacin and BAK showed additive effects against bacteria and provided delayed release of both agents.

Conclusions: The use of combined antibiotic-loaded hydrogel coatings provides a promising approach to combating the development of VAP.

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通过联合抗生素负载增强抗菌释放性能的气管导管抗菌涂层的研制。

背景：呼吸机相关性肺炎（VAP）是世界范围内患者发病和死亡的重要原因。本研究描述了一种开发用于气管插管的抗菌水凝胶涂层的策略，该涂层由2-羟乙基甲基丙烯酸酯和甲基丙烯酸组成，能够同时提供抗菌剂组合以减轻VAP。方法：将庆大霉素、左氧氟沙星和苯扎氯铵（BAK）分别负载在共聚物水凝胶中，测定其药物释放谱、抗菌活性和持续时间。关键发现：4 h和24 h后，所有含抗生素水凝胶的细菌粘附率分别降低95%和99.99%以上。负载BAK的水凝胶对金黄色葡萄球菌的保护作用超过30天，负载左氧氟沙星的水凝胶对铜绿假单胞菌的保护作用超过10天。左氧氟沙星和BAK的双重负载对细菌具有加性作用，并具有缓释作用。结论：联合应用含抗生素的水凝胶涂层是防治VAP的有效途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacy and Pharmacology 医学-药学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.