Insulin-like growth factor-binding protein 3 and incidence of pancreatic cancer in a nested case-control study.

IF 2.2 4区医学 Q3 ONCOLOGY

Japanese journal of clinical oncology Pub Date : 2025-09-18 DOI:10.1093/jjco/hyaf146

Yasushi Adachi, Masanori Nojima, Yingsong Lin, Yoshiharu Masaki, Yasushi Sasaki, Hiroshi Nakase, Kenji Wakai, Mitsuru Mori, Akiko Tamakoshi

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引用次数: 0

Abstract

Background: Insulin-like growth factors (IGFs) are potent mitogens and IGF-binding protein 3 (IGFBP3) can regulate IGF activity. To elucidate relationships between IGF-related molecules and risk of pancreatic cancer, we analyzed associations between serum levels of IGF1 and IGFBP3 and incidence of pancreatic cancer in a prospective, nested, case-control study within the Japan Collaborative Cohort study.

Methods: A baseline survey was conducted from 1988 to 1990, during which period blood samples were obtained from 39 242 subjects. Subjects who had been diagnosed with pancreatic cancer by 1997 were regarded as cases. Conditional logistic regression was used to estimate odds ratios (ORs) for the incidence of pancreatic cancer in relation to serum levels of IGF1 and IGFBP3.

Results: This analysis included 72 cases and 216 controls. Free IGFBP3 (estimated as IGFBP3-IGF1) was associated with the risk of pancreatic cancer (P for trends = 0.011), with the third tertile showing the highest risk (OR = 3.42, 95%CI = 1.31-8.91). None of total IGF1, free IGF1 (estimated as IGF1/IGFBP3), or total IGFBP3 were associated with risk of pancreatic cancer. This result remained unchanged in subanalyses of male, female, and older subjects (P for trends = 0.017, 0.030, and 0.007, respectively). When limiting analysis to participants followed for over 2 years, free IGFBP3 was associated with risk of pancreatic cancer (P for trends = 0.025).

Conclusions: Our findings suggest that free IGFBP3 is associated with the risk of pancreatic cancer.

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胰岛素样生长因子结合蛋白3与胰腺癌发病率的巢式病例对照研究

背景：胰岛素样生长因子（IGFs）是有效的丝裂原，IGF结合蛋白3 （IGFBP3）可以调节IGF活性。为了阐明igf相关分子与胰腺癌风险之间的关系，我们在日本合作队列研究中进行了一项前瞻性、嵌套式、病例对照研究，分析了血清IGF1和IGFBP3水平与胰腺癌发病率之间的关系。方法：1988 - 1990年进行基线调查，抽取39242人血液样本。在1997年之前被诊断为胰腺癌的受试者被视为病例。使用条件逻辑回归来估计胰腺癌发病率与血清IGF1和IGFBP3水平的比值比（ORs）。结果：本分析纳入72例病例和216例对照。游离IGFBP3（估计为IGFBP3- igf1）与胰腺癌的风险相关（趋势P = 0.011），其中第三个五分位数显示最高的风险（OR = 3.42, 95%CI = 1.31-8.91）。总IGF1、游离IGF1（估计为IGF1/IGFBP3）或总IGFBP3与胰腺癌风险无关。这一结果在男性、女性和老年受试者的亚分析中保持不变（趋势P分别= 0.017、0.030和0.007）。当对随访超过2年的参与者进行限制分析时，游离IGFBP3与胰腺癌的风险相关（趋势P = 0.025）。结论：我们的研究结果表明游离IGFBP3与胰腺癌的风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese journal of clinical oncology 医学-肿瘤学

CiteScore

3.70

自引率

8.30%

发文量

177

审稿时长

3-8 weeks

期刊介绍： Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews