Effects of exercise on body composition, fitness, and blood pressure in overweight or obese patients with MASLD: A systematic review and meta-analysis.
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引用次数: 0
Abstract
Objective: To systematically evaluate the effects of exercise on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with metabolic dysfunction-associated steatotic liver disease (MASLD), to provide evidence-based guidance for individualized exercise prescription.
Methods: A systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials published from database inception to April 2025. Eligible studies included overweight or obese patients with MASLD, and the intervention consisted of various types of exercise training. The primary outcome measures included body mass index (BMI), body fat percentage, waist circumference, maximal oxygen uptake (VO₂ max), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Meta-analysis was performed using Review Manager version 5.4 and Stata version 16.
Results: A total of 26 articles comprising 29 studies and 1123 participants were included. The meta-analysis showed that, exercise interventions were associated with a significant reduction in BMI (SMD = -0.28, P = 0.000) and waist circumference (SMD = -0.41, P = 0.000), while the reduction in body fat percentage did not reach statistical significance (SMD = -0.25, P = 0.061). Regarding blood pressure, exercise significantly decreased DBP (SMD = -0.38, P = 0.000), while the decrease in SBP showed a non-significant trend toward reduction (SMD = -0.26, P = 0.071). In terms of cardiorespiratory fitness, exercise interventions significantly improved VO₂ max (SMD = 0.75, P = 0.000), indicating a notable enhancement in cardiovascular function.
Conclusion: Exercise interventions have a positive impact on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with MASLD. The most pronounced effects were observed in the improvement of VO₂ max, waist circumference, and DBP.
期刊介绍：
Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD).
Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology.
Contributions consist of:
Original Papers
Correspondence to the Editor
Editorials, Reviews and Special Articles
Progress Reports
Image of the Month
Congress Proceedings
Symposia and Mini-symposia.
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