Association between Hidradenitis Suppurativa and Peripheral Arterial Occlusion Disease: a propensity-score-matched cohort study.

IF 2.8 4区 医学 Q1 DERMATOLOGY
Hui-Chin Chang, Shao-Wei Lo, Yun-Feng Li, Tsu-Man Chiu, Chao-Bin Yeh, Yi-Sheng Jhang, Shiu-Jau Chen, Shuo-Yan Gau
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引用次数: 0

Abstract

Background: Considering the plausible mechanistic associations and the significant clinical implications of Hidradenitis suppurativa (HS) and peripheral arterial occlusive disease (PAOD), this study aimed to investigate the risk of incident PAOD in patients with HS.

Method: A retrospective cohort study using the TriNetX research network was conducted. HS patients were matched 1:1 with non-HS controls based on demographic and clinical factors. The primary outcome was the incidence of PAOD, analyzed using hazard ratios (HRs) and Kaplan-Meier curves over a 15-year follow-up period. Sensitivity and stratification analyses were performed to validate the findings.

Result: Over a 15-year follow-up, HS patients demonstrated a significantly higher risk of developing PAOD compared to matched controls (HR 1.230, 95% CI 1.164-1.300) in the crude model. This risk persisted after adjusting for possible confounders. Kaplan-Meier analysis showed a higher cumulative probability of PAOD in the HS cohort (adjusted HR 1.478, 95% CI 1.357-1.610, log-rank p-value of <0.01) over the entire follow-up period. Sensitivity analyses confirmed the robustness of these findings across various models. Stratification analyses indicated consistent PAOD risk across gender and age subgroups, with higher risks observed in males (HR 1.794, 95% CI 1.541-2.089) and patients aged ≥65 years (HR 1.769, 95% CI 1.534-2.039).

Conclusion: HS is associated with an increased risk of PAOD, independent of traditional cardiovascular risk factors. These findings underscore the importance of cardiovascular risk assessment and management in patients with HS. Further research is needed to elucidate the underlying mechanisms and evaluate the impact of HS treatment on PAOD risk.

化脓性汗腺炎与外周动脉闭塞疾病之间的关系:一项倾向评分匹配的队列研究。
背景:考虑到化脓性汗腺炎(HS)和外周动脉闭塞性疾病(pad)之间可能的机制关联和重要的临床意义,本研究旨在探讨HS患者发生pad的风险。方法:采用TriNetX研究网络进行回顾性队列研究。根据人口学和临床因素,HS患者与非HS对照组进行1:1匹配。主要终点是pad的发生率,通过15年随访期间的风险比(hr)和Kaplan-Meier曲线进行分析。进行敏感性和分层分析以验证研究结果。结果:经过15年的随访,在粗模型中,HS患者发生pad的风险明显高于对照组(HR 1.230, 95% CI 1.164-1.300)。在调整了可能的混杂因素后,这种风险仍然存在。Kaplan-Meier分析显示HS队列中pad的累积概率较高(调整后的HR为1.478,95% CI为1.357-1.610,对数秩p值为)。结论:HS与pad风险增加相关,独立于传统心血管危险因素。这些发现强调了HS患者心血管风险评估和管理的重要性。需要进一步的研究来阐明其潜在机制并评估HS治疗对pad风险的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
2.40%
发文量
389
审稿时长
3-8 weeks
期刊介绍: Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.
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