Surface-engineered MnO₂@Au@ZIF-67 hierarchical catalysts for acid-triggered antibacterial therapy and infected wound healing

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-16 DOI:10.1016/j.colsurfb.2025.115145

Mengmeng Xu , Yuan Liu , Zhe Tang , Xiaolin Yu , Li Gao , Bo Yang , Yan Wang , Xuehui Dong , Qianqian Yu , LinGe Wang

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引用次数: 0

Abstract

Rational surface engineering of nanocatalysts offers new solutions against antibiotic-resistant infections. We designed and fabricated hierarchical MnO₂@Au@ZIF-67 nanoparticles (NPs) with triple interfacial functionalities for synergistic antibacterial therapy. The acid-responsive ZIF-67 surface degrades in infected wounds, releasing Co²⁺ to catalyze •OH generation via Fenton-like reactions at the material-bacteria interface. Simultaneously, ultrasmall Au surfaces deplete glucose through oxidase-mimetic catalysis, producing gluconic acid that accelerates ZIF-67 dissolution. The MnO₂ core surface decomposes H₂O₂ to supply O₂, enhancing Au catalysis and alleviating hypoxia. Comprehensive surface characterization (TEM, SEM, XPS, XRD) confirmed structural integrity and reactive sites. In vitro, the NPs achieved > 99 % bacterial killing (S. aureus/E. coli) through ROS-mediated membrane disruption (validated by SEM/CLSM). In vivo, they enabled 98.45 % bacterial clearance and accelerated wound healing via collagen reorganization (H&E/Masson staining). This surface-engineered platform demonstrates how interfacial catalytic cascades can be harnessed for effective non-antibiotic antimicrobial applications.

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表面工程mno2 @Au@ZIF-67分级催化剂用于酸触发的抗菌治疗和感染伤口愈合。

合理的纳米催化剂表面工程为抗抗生素耐药感染提供了新的解决方案。我们设计并制造了具有三重界面功能的层次化MnO₂@Au@ZIF-67纳米颗粒（NPs），用于协同抗菌治疗。酸敏感的ZIF-67表面在感染的伤口中降解，释放Co 2⁺在材料-细菌界面上通过芬顿样反应催化•OH生成。同时，超小的金表面通过模拟氧化酶的催化作用消耗葡萄糖，产生葡萄糖酸，加速ZIF-67的溶解。MnO₂核心表面分解h2o₂供给O₂，增强Au催化作用，缓解缺氧。综合表面表征（TEM， SEM， XPS， XRD）证实了结构的完整性和活性位点。在体外，NPs达到> 99 %的细菌杀灭率（金黄色葡萄球菌/E）。通过ros介导的膜破坏（通过SEM/CLSM验证）。在体内，它们使98.45% %的细菌清除率，并通过胶原重组加速伤口愈合（H&E/Masson染色）。这个表面工程平台展示了如何利用界面催化级联进行有效的非抗生素抗菌应用。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.