Sensitivity Enhancement of Plasmonic Sensor Using Dual Aluminum Oxide Nitride Layers for Chikungunya Virus Detection: A Numerical Analysis

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-01-23 DOI:10.1007/s11468-024-02751-1

Hussein S. Gumaih, Md. Aslam Mollah, Yousif S. Adam, Abdulkarem H. M. Almawgani

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引用次数: 0

Abstract

Chikungunya is an RNA virus transmitted through mosquito bites, leading to symptoms such as fever, joint swelling, discomfort, and muscle soreness. This article proposes a surface plasmon resonance (SPR)-based biosensor for chikungunya virus detection, utilizing the Kretschmann configuration. The sensor’s structure includes a BK7 prism, silver (Ag), and dual layers of aluminum oxide nitride (AION). The proposed sensor is used for analyte detection by investigating refractive index (RI) changes. Numerical analysis of the proposed sensor’s reflectivity is conducted using the transfer matrix method (TMM). Optimal sensor parameters show maximum sensitivity for platelets and plasma cells of 438 °/RIU and 321 °/RIU, respectively, with figures of merit (FOM) of 143 RIU⁻¹ and 188 RIU⁻¹, detection accuracy (DA) of 0.33 /°and 0.58 /°, and signal-to-noise ratio (SNR) of 1.43 and 1.88. Sensitivity enhancement is explored by varying the number and thickness of layers. The sensor performance is justified by finite element method (FEM) based COMSOL software. The sensor’s high sensitivity and stability make it potentially useful for biomedical applications.

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双氧化铝氮化层等离子体传感器检测基孔肯雅病毒的灵敏度增强：数值分析

基孔肯雅热是一种通过蚊虫叮咬传播的RNA病毒，会导致发烧、关节肿胀、不适和肌肉酸痛等症状。本文提出一种基于表面等离子体共振（SPR）的基孔肯雅病毒检测生物传感器，利用Kretschmann结构。该传感器的结构包括一个BK7棱镜、银（Ag）和双层氧化氮化铝（AION）。该传感器通过研究折射率（RI）变化用于分析物检测。采用传递矩阵法（TMM）对传感器的反射率进行了数值分析。最佳传感器参数对血小板和浆细胞的最大灵敏度分别为438°/RIU和321°/RIU，优点值（FOM）为143 RIU−1和188 RIU−1，检测精度（DA）为0.33 /°和0.58 /°，信噪比（SNR）为1.43和1.88。通过改变层数和层厚来提高灵敏度。采用基于COMSOL软件的有限元法对传感器的性能进行了验证。该传感器的高灵敏度和稳定性使其在生物医学应用中具有潜在的用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.