Sensitivity Enhancement Using Surface Plasmon Resonance Sensor for Colorectal Detection by Employing Heterostructure

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-01-13 DOI:10.1007/s11468-024-02735-1

Kalpana N., Abdullah N. Alodhayb, Saravanan Pandiaraj, Shivam Singh

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引用次数: 0

Abstract

This article proposes a surface plasmon resonance (SPR) sensor based on heterostructure (MXene/h-BN/BP) for colorectal cancer detection. Surface plasmons (SPs) have been excited using the prism-based setup. The silver (Ag) layer on the CaF₂ prism makes up the structure of the proposed sensor. To increase the stability of the Ag layer, a heterostructure layer is applied on top. Both normal and colorectal tissues are used as the analyte medium to detect colorectal cancer. The transfer matrix method has been used to carry out the sensor’s numerical simulations. The proposed sensor’s performance is determined by its sensitivity, detection accuracy (DA), and figure of merit (FoM), which takes into account the SPR curve’s dip strength and full width at half maxima (FWHM). The sensitivity and FoM 315.30°/RIU and 52.34/RIU are obtained, respectively. The maximal sensitivity of 322.21°/RIU is achieved. Additionally, the penetration depth (PD) is achieved at 218.81 nm with the normal tissue. The proposed sensor would be a good candidate for biosensors and medical diagnostics.

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利用异质结构增强表面等离子体共振传感器检测结肠直肠的灵敏度

本文提出了一种基于异质结构（MXene/h-BN/BP）的表面等离子体共振（SPR）传感器，用于结直肠癌检测。表面等离子体激元（SPs）已经使用基于棱镜的装置被激发。在CaF2棱镜上的银（Ag）层构成了该传感器的结构。为了提高银层的稳定性，在银层顶部加了异质结构层。正常组织和结直肠组织都被用作检测结直肠癌的分析介质。采用传递矩阵法对传感器进行了数值模拟。该传感器的性能由其灵敏度、检测精度（DA）和性能因数（FoM）决定，其中考虑了SPR曲线的倾斜强度和半最大值时的全宽度（FWHM）。灵敏度为315.30°/RIU， FoM为52.34°/RIU。最大灵敏度达到322.21°/RIU。此外，在正常组织中，穿透深度（PD）达到218.81 nm。所提出的传感器将是生物传感器和医学诊断的良好候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.