Validation of ICP-OES and γ-spectrometry methodologies for quality assessment of 67Cu from cyclotron production via the 70Zn(p,α)67Cu nuclear reaction

IF 1.6 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-07-31 DOI:10.1007/s10967-025-10270-4

Ursula Søndergaard, Kolle E. Thomas, Rune Sundset, Claire Deville, Mikael Jensen, Kristina S. Pedersen, Angel Moldes-Anaya

{"title":"Validation of ICP-OES and γ-spectrometry methodologies for quality assessment of 67Cu from cyclotron production via the 70Zn(p,α)67Cu nuclear reaction","authors":"Ursula Søndergaard, Kolle E. Thomas, Rune Sundset, Claire Deville, Mikael Jensen, Kristina S. Pedersen, Angel Moldes-Anaya","doi":"10.1007/s10967-025-10270-4","DOIUrl":null,"url":null,"abstract":"<div>Increasing interest in 67Cu for targeted radionuclide therapy necessitates development of robust and validated analytical methods to ensure compliance with regulatory standards for clinical translation. We validated methods based on inductively coupled plasma optical emission spectroscopy (ICP-OES) and high-purity germanium (HPGe) γ-spectrometry. For ICP-OES, criteria were met for most elements, with Al and Ca, suffering matrix effects. Apparent molar activity calculated by ICP-OES was congruent with DOTA-titration-based effective molar activity when Al and Ca were excluded. HPGe γ-spectrometry was shown to enable accurate discrimination and quantification of co-produced radionuclides (67Ga, 66Ga, 69mZn) from 67Cu at 99.5% radionuclidic purity.</div>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":"334 8","pages":"5637 - 5648"},"PeriodicalIF":1.6000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10967-025-10270-4.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radioanalytical and Nuclear Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10967-025-10270-4","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Increasing interest in ⁶⁷Cu for targeted radionuclide therapy necessitates development of robust and validated analytical methods to ensure compliance with regulatory standards for clinical translation. We validated methods based on inductively coupled plasma optical emission spectroscopy (ICP-OES) and high-purity germanium (HPGe) γ-spectrometry. For ICP-OES, criteria were met for most elements, with Al and Ca, suffering matrix effects. Apparent molar activity calculated by ICP-OES was congruent with DOTA-titration-based effective molar activity when Al and Ca were excluded. HPGe γ-spectrometry was shown to enable accurate discrimination and quantification of co-produced radionuclides (⁶⁷Ga, ⁶⁶Ga, ^69mZn) from ⁶⁷Cu at 99.5% radionuclidic purity.

查看原文本刊更多论文

用ICP-OES和γ-光谱法评价70Zn(p,α)67Cu核反应回旋产物中67Cu的质量

67Cu用于靶向放射性核素治疗的兴趣日益增加，需要开发强大且经过验证的分析方法，以确保符合临床翻译的监管标准。我们验证了电感耦合等离子体发射光谱（ICP-OES）和高纯锗(HPGe) γ光谱法的方法。ICP-OES中，除Al和Ca受基质效应影响外，大多数元素符合标准。当排除Al和Ca时，ICP-OES计算的表观摩尔活性与dota滴定法计算的有效摩尔活性一致。HPGe γ能谱法能够以99.5%的放射性核素纯度对67Cu共同产生的放射性核素（67Ga, 66Ga, 69mZn）进行准确的鉴别和定量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.