Highly Sensitive Surface Plasmon Resonance Cancer Cell Biosensor Based on BlueP/TMDCs and MXene Heterostructure

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-01-31 DOI:10.1007/s11468-024-02729-z

Wentao Xu, Tao Liu, Yanhua Ma, Min Jin, Fuxiang Wang, Chunmao Fan, Zhi Zhangyong, Lei Han

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引用次数: 0

Abstract

Cancer has become a critical global health issue, highlighting the urgent need for detection methods that are both fast and highly accurate. This study presents an advanced surface plasmon resonance (SPR) biosensor for detecting various cancer cell types (Jurkat, PC12, HeLa), utilizing a hybrid structure with two-dimensional (2D) materials, such as MXene (Ti3C2Tx) and a composite of blue phosphorene with transition metal dichalcogenides (BlueP/TMDCs). Simulation software MATLAB was used to model the SPR biosensor, assessing its sensitivity and figure of merit (FOM). Optimal sensitivity, reaching 251.21°/RIU, was achieved with a monolayer of MXene and a bilayer of BlueP/WS₂, specifically detecting PC12 (adrenal glands cells). Compared with the traditional silver (Ag) film used in standard SPR biosensors, this hybrid structure with BlueP/WS₂ demonstrated a 50% increase in sensitivity. SPR biosensors have shown significant advancements in sensitivity and precision over current clinical diagnostic methods, providing a robust foundation for early disease diagnosis and treatment.

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基于BlueP/TMDCs和MXene异质结构的高灵敏度表面等离子体共振癌细胞生物传感器

癌症已成为一个严重的全球卫生问题，这突出表明迫切需要既快速又高度准确的检测方法。本研究提出了一种先进的表面等离子体共振（SPR）生物传感器，用于检测各种类型的癌细胞（Jurkat, PC12, HeLa），利用二维（2D）材料的混合结构，如MXene （Ti3C2Tx）和蓝色磷烯与过渡金属二硫族化合物（BlueP/TMDCs）的复合材料。利用MATLAB仿真软件对SPR生物传感器进行建模，评估其灵敏度和优值图（FOM）。单层MXene和双层BlueP/WS2特异性检测PC12（肾上腺细胞），灵敏度达到251.21°/RIU。与标准SPR生物传感器中使用的传统银（Ag）膜相比，这种与BlueP/WS2混合结构的灵敏度提高了50%。与目前的临床诊断方法相比，SPR生物传感器在灵敏度和精度上都有了显著的进步，为疾病的早期诊断和治疗提供了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.