Advancements in Fiber and Prism-Based Surface Plasmon Resonance Sensors: Comparative Analysis and Applications in Disease Detection and Biosensing

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-02-05 DOI:10.1007/s11468-024-02745-z

Purnendu Shekhar Pandey, Azhar Shadab, Malatesh Akkur, Yashpal Yadav, Manoj Kumar, Mahaveer Singh Naruka, Yadvendra Singh, Rajesh Singh

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引用次数: 0

Abstract

The surface plasmon resonance (SPR) technique has proven indispensable as an optical sensing method owing to its extraordinary sensitivity to changes in refractive index, making it crucial for diagnosis of disease diagnostics, environmental assessment, and pharmaceutical development. This review compares the two most common configurations of SPR sensors: fiber-based and prism-based SPR sensors. This comprehensive review covers various sensor configurations, geometric shapes, and fiber types, advantages of each in terms of integration, sensitivity, and performance enhancement. Significant applications include diagnosis of Alzheimer’s disease, cardiovascular conditions, cancer, and diabetes. Fiber SPR sensors offer real-time monitoring, mobility, and field flexibility; on the other hand, prism-based SPR sensors provide a higher sensitivity and are more relevant for laboratory applications that demand accuracy. The integration of advanced nanomaterials like graphene and MXenes has further improved both systems’ sensitivity and stability. Recent advances in miniaturization and multiplexing enabled them to be adapted for real-time biomarker detection of various medical diagnostics based on environmental safety, providing the tools of modern biosensing technology.

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基于纤维和棱镜的表面等离子体共振传感器的进展：比较分析及其在疾病检测和生物传感中的应用

表面等离子体共振（SPR）技术由于其对折射率变化的非凡敏感性，已被证明是一种不可或缺的光学传感方法，使其在疾病诊断、环境评估和药物开发中至关重要。本文比较了两种最常见的SPR传感器配置：基于光纤的SPR传感器和基于棱镜的SPR传感器。这篇全面的综述涵盖了各种传感器配置、几何形状和光纤类型，以及每种传感器在集成、灵敏度和性能增强方面的优势。重要的应用包括阿尔茨海默病、心血管疾病、癌症和糖尿病的诊断。光纤SPR传感器提供实时监控、机动性和现场灵活性；另一方面，基于棱镜的SPR传感器提供更高的灵敏度，并且更适合要求精度的实验室应用。石墨烯和MXenes等先进纳米材料的集成进一步提高了系统的灵敏度和稳定性。小型化和多路复用的最新进展使它们能够适应基于环境安全的各种医学诊断的实时生物标志物检测，为现代生物传感技术提供了工具。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.