Design and Analysis of Surface Plasmon Resonance Refractive Index Biosensor with Label-Free Detection of Anemia, HIV, and Cholesterol Samples

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-01-27 DOI:10.1007/s11468-025-02763-5

Trupti Kamani, Shobhit K. Patel, Ammar Armghan, Habib Kraiem

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引用次数: 0

Abstract

The development of accurate and exceptionally sensitive biosensors for the prompt identification of critical health issues is of paramount importance for healthcare diagnostics. The design and analysis of the SPR-based trio-square nest-shaped refractive index biosensor (TSNSRIB) for the recognition of cholesterol, anemia, and HIV-infected cells have been demonstrated in the presented research work by utilizing COMSOL Multiphysics simulation software. The sensor leverages SPR’s inherent sensitivity to figure out shifts in the refractive index across the metal-dielectric interaction caused by biomolecular interactions. The biosensor uses specialized bio-recognition components that measure the amount of hemoglobin for anemia testing, HIV-specific antibodies for HIV screening, and cholesterol molecules for cardiovascular risk estimation. The excellent sensitivity of 700 nm/RIU for sensing an anemia sample with a quality factor value of 4095.47 has been obtained. The excellent figure of merit value is 1898.56 with the lowest detection limit of 0.000127 for anemia detection in comparison to the HIV sample and cholesterol sample. These findings draw attention to the biosensor’s capability to boost diagnostic capabilities and lead to improved outcomes for healthcare.

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表面等离子体共振折射率生物传感器的设计与分析，用于无标记检测贫血、HIV和胆固醇样品

开发准确和异常敏感的生物传感器，以迅速识别关键的健康问题，对医疗保健诊断至关重要。利用COMSOL Multiphysics仿真软件，设计和分析了基于spr的三方巢形折射率生物传感器（TSNSRIB），用于识别胆固醇、贫血和hiv感染细胞。该传感器利用SPR固有的灵敏度来计算由生物分子相互作用引起的金属-介电相互作用中折射率的变化。该生物传感器使用专门的生物识别组件来测量血红蛋白的数量，用于贫血测试，HIV特异性抗体用于HIV筛查，胆固醇分子用于心血管风险评估。检测贫血样品的灵敏度为700 nm/RIU，质量因子值为4095.47。与HIV样品和胆固醇样品相比，贫血检测的优优值为1898.56，最低检出限为0.000127。这些发现引起了人们对生物传感器提高诊断能力和改善医疗保健结果的关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.