Design and Analysis of Twin-Core Side-Polished SPR PCF Sensor for Preliminary Malaria Detection

IF 4.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL
Devi Kangan B S, Akash Khamaru, Ajeet Kumar
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Abstract

This paper proposes a double-side polished twin-core photonic crystal fiber (PCF)-based surface plasmon resonance (SPR) sensor for early-stage detection of malaria. The analysis and the assessment of the proposed sensor are done by finite element method using the COMSOL Multiphysics software. The dual-side polished structure reduces the distance between the metal layer and core mode, thereby enhancing the sensor performance due to the strong coupling between them. The air holes arrangement resembles the shape of an “hourglass” which helps to confine light energy within the twin cores. A layer of gold, a preferred plasmonic material, is coated on the symmetrically polished surface of the PCF to induce SPR. Due to distinction in the refractive indices, the resonance wavelength is different for infected and normal red blood cells (RBCs). The analysis is done for infected RBCs (ring phase, trophozoite phase, and schizont phase). The structural parameters are optimized precisely and a maximum wavelength sensitivity of 26,428.57 nm/RIU was achieved for the ring phase, 16,052.6 nm/RIU for the trophozoite phase, and 12,586.2 nm/RIU for the schizont phase. The numerical analysis also shows that the sensor possess high figure-of-merit (FOM) values of 334.54 RIU−1, 321.05 RIU−1, and 381.40 RIU−1 for the ring, trophozoite, and schizont phases, respectively. These results confirm the potential of the proposed sensor and also justify its betterment than the existing methods. Due to its promising sensing performance and appropriate FOM value, the proposed sensor is suitable for the early-stage malaria detection.

用于疟疾初步检测的双芯侧抛光SPR PCF传感器设计与分析
提出了一种用于疟疾早期检测的双面抛光双核光子晶体光纤(PCF)表面等离子体共振(SPR)传感器。利用COMSOL Multiphysics软件对传感器进行了有限元分析和评估。双面抛光结构减小了金属层与芯模之间的距离,由于金属层与芯模之间的强耦合,从而提高了传感器的性能。空气孔的排列类似于“沙漏”的形状,有助于将光能限制在双核心内。在PCF的对称抛光表面涂覆一层金(一种优选的等离子体材料)以诱导SPR。由于折射率的不同,感染红细胞和正常红细胞的共振波长不同。对感染的红细胞(环状期、滋养体期和分裂体期)进行分析。对结构参数进行了精确优化,环形相、营养体相和分裂体相的最大波长灵敏度分别为26,428.57 nm/RIU、16,052.6 nm/RIU和12,586.2 nm/RIU。数值分析还表明,该传感器在环相、滋养体相和分裂体相中分别具有334.54 RIU−1、321.05 RIU−1和381.40 RIU−1的优异值。这些结果证实了所提出的传感器的潜力,也证明了它比现有的方法更好。该传感器具有良好的传感性能和合适的FOM值,适用于疟疾早期检测。
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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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