Research and development of natural product Salidroside: Pharmacology, total synthesis and structural modifications

IF 5.9 2区医学 Q1 CHEMISTRY, MEDICINAL

European Journal of Medicinal Chemistry Pub Date : 2025-09-19 DOI:10.1016/j.ejmech.2025.118186

Mingjing Zhao , Nan Wu , Yan Piao , Chonghao Sun, Junyi Jin, Chengyu Cui, Peng Du, Xiongjie Yin, Lili Jin, Changhao Zhang

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引用次数: 0

Abstract

Salidroside (SAL) is a glycoside compound with good biological activity, which has multi-target therapeutic potential for various disease. It can significantly regulate various receptors, inflammatory mediators and signaling pathways. However, due to the problems of low content of natural sources, difficulty in isolation and purification and poor bioavailability, SAL cannot be widely used in clinical treatment. This article reviews the chemical total synthesis methods and the typical pharmacological effects of SAL, mainly about anti-tumor, anti-hypoxia and anti-sepsis fields. In addition, this article focuses on summarizing the research progress on the structural modification of SAL. Summarized the structure-activity relationship of SAL and its derivatives. These contents can enhance scholars’ understanding of the current research progress on SAL, overcome the limitations which SAL is faced, and provide constructive insights for further development of new drugs based on SAL.

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天然产物红景天苷的研究与开发：药理学、全合成和结构修饰

红景天苷（Salidroside， SAL）是一种具有良好生物活性的糖苷类化合物，对多种疾病具有多靶点治疗潜力。它能显著调节多种受体、炎症介质和信号通路。但由于天然来源含量低、分离纯化困难、生物利用度差等问题，尚不能广泛应用于临床治疗。本文综述了SAL的化学全合成方法及其典型药理作用，主要涉及抗肿瘤、抗缺氧和抗败血症等方面。此外，本文还重点综述了SAL结构改性的研究进展。综述了SAL及其衍生物的构效关系。这些内容可以增进学者对SAL目前研究进展的了解，克服SAL面临的局限，为进一步开发基于SAL的新药提供建设性的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medicinal Chemistry 化学-医药化学

CiteScore

11.70

自引率

9.00%

发文量

863

审稿时长

29 days

期刊介绍： The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.