Recurrent lesion distribution after photodynamic therapy for recurrent respiratory papillomatosis

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-09-16 DOI:10.1016/j.pdpdt.2025.105223

Yufei Pan , Huili Huang , Ke Wu , Xiao Han , Huiying Hu , Kai Liu , Yuanyuan Lu , Zhenkun Yu

{"title":"Recurrent lesion distribution after photodynamic therapy for recurrent respiratory papillomatosis","authors":"Yufei Pan , Huili Huang , Ke Wu , Xiao Han , Huiying Hu , Kai Liu , Yuanyuan Lu , Zhenkun Yu","doi":"10.1016/j.pdpdt.2025.105223","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Recurrent respiratory papillomatosis (RRP) is a benign laryngeal tumor, and traditional surgical resection faces the dilemma between excessive tissue removal and high recurrence rates. Photodynamic therapy (PDT), as a \"regional clearance\" strategy, offers a novel approach to addressing this challenge. However, the anatomical distribution of recurrent lesions following PDT has not been fully elucidated.</div></div><div><h3>Objective</h3><div>To evaluate the distribution characteristics of recurrent lesions in different anatomical regions following PDT for RRP, thereby providing evidence to optimize PDT treatment protocols.</div></div><div><h3>Methods</h3><div>A retrospective study analyzed 43 RRP patients who underwent PDT (January 2021-December 2024), with 54 recurrence records examined. Postoperative laryngoscopic examinations were performed monthly to assess recurrence. An 11-region anatomical diagram was used to assess lesion distribution and calculate relative recurrence rates across anterior and posterior regions. In-situ and ectopic recurrences were statistically compared.</div></div><div><h3>Results</h3><div>The study found that the epiglottis exhibited the highest relative recurrence rate (75.00 %), indicating it is more prone to recurrence than other regions (<em>χ²</em> = 21.850, <em>P</em> = 0.016). Additionally, the recurrence rate in the posterior regions (63.16 %) was higher than that in the anterior regions (50.00 %) (<em>χ²</em> = 3.54, <em>P</em> = 0.060). Furthermore, in-situ recurrence significantly outweighed ectopic recurrence (<em>χ²</em> = 111.24, <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>During PDT for RRP, statistically significant differences in relative recurrence rates were observed across anatomical regions, with in-situ recurrence being the most common pattern.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105223"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025007549","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Recurrent respiratory papillomatosis (RRP) is a benign laryngeal tumor, and traditional surgical resection faces the dilemma between excessive tissue removal and high recurrence rates. Photodynamic therapy (PDT), as a "regional clearance" strategy, offers a novel approach to addressing this challenge. However, the anatomical distribution of recurrent lesions following PDT has not been fully elucidated.

Objective

To evaluate the distribution characteristics of recurrent lesions in different anatomical regions following PDT for RRP, thereby providing evidence to optimize PDT treatment protocols.

Methods

A retrospective study analyzed 43 RRP patients who underwent PDT (January 2021-December 2024), with 54 recurrence records examined. Postoperative laryngoscopic examinations were performed monthly to assess recurrence. An 11-region anatomical diagram was used to assess lesion distribution and calculate relative recurrence rates across anterior and posterior regions. In-situ and ectopic recurrences were statistically compared.

Results

The study found that the epiglottis exhibited the highest relative recurrence rate (75.00 %), indicating it is more prone to recurrence than other regions (χ² = 21.850, P = 0.016). Additionally, the recurrence rate in the posterior regions (63.16 %) was higher than that in the anterior regions (50.00 %) (χ² = 3.54, P = 0.060). Furthermore, in-situ recurrence significantly outweighed ectopic recurrence (χ² = 111.24, P < 0.001).

Conclusion

During PDT for RRP, statistically significant differences in relative recurrence rates were observed across anatomical regions, with in-situ recurrence being the most common pattern.

查看原文本刊更多论文

光动力治疗复发性呼吸道乳头状瘤后复发病变分布。

背景：复发性呼吸道乳头状瘤病（RRP）是喉良性肿瘤，传统手术切除面临过度组织切除和高复发率的困境。光动力疗法（PDT）作为一种“区域清除”策略，为解决这一挑战提供了一种新的方法。然而，PDT后复发病变的解剖分布尚未完全阐明。目的：评价RRP术后复发病灶在不同解剖区域的分布特点，为优化PDT治疗方案提供依据。方法：回顾性分析43例接受PDT治疗的RRP患者（2021年1月- 2024年12月），其中54例复发记录。术后每月进行喉镜检查以评估复发情况。使用11区解剖图来评估病变分布并计算前后区相对复发率。对原位复发和异位复发进行统计学比较。结果：研究发现会咽的相对复发率最高（75.00%），较其他部位更容易复发（χ² = 21.850,P = 0.016）。后区复发率（63.16%）高于前区复发率（50.00%）（χ² = 3.54,P = 0.060）。此外，原位复发率显著高于异位复发率（χ² = 111.24,P < 0.001）。结论：在RRP的PDT治疗过程中，不同解剖区域的相对复发率差异有统计学意义，以原位复发为最常见的模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.