Prevalence, Distribution, and Risk Factors of Mycobacterium Other Than Tuberculosis Among Tuberculosis Presumptive Patients in Karonga District in Malawi

IF 2.3 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2025-09-18 DOI:10.1111/crj.70126

S. Chitsulo, L. Gogoda, H. Nyirenda, S. Chirwa, T. Mwenyenkulu, H. Kanyerere, J. Mpunga, K. Mbendera, B. Mbakaya, S. Mwale, B. Nyambalo, F. Sinyiza, M. Chisale

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引用次数: 0

Abstract

Introduction

Besides tuberculosis (TB), there are also other nontuberculous mycobacteria (NTM) that present with similar clinical signs and symptoms as TB. If not promptly found and treated, these organisms may affect the programming of the TB control and elimination campaign. The study sought to establish the prevalence, distribution, and factors contributing to MOTT infections among presumptive TB patients in the Karonga district.

Methods

A descriptive cross-sectional study research design was employed. A total of 196 participants were included in the study using a census approach. Data were collected by administering a questionnaire to the health care worker, and a sputum specimen was collected from the participants; this specimen was used to examine the presence of mycobacterium using the microscope. Regardless of the results at the district-level laboratory, all the specimens were then sent to the Mzuzu region TB reference laboratory to isolate Mycobacterium tuberculosis and Mycobacterium Other Than Tuberculosis.

Results

Of the 196 samples collected, 14 (7.1%) were positive at the district level. When sent for culture, 195 (99.5%) had culture results, and 23 (12%) had growth in culture. Out of the 23 (100%) culture-positive results, 12 (52%) were MOTT-positive, while 11 (48%) were MTB complex. There were more men, seven (58%) with MOTT-positive than women, five (42%), and more in the age group of 15–39 years old, with six (50%) and less in more than 60 years old two (16.7%).

Conclusion

The results show the presence of MOTT infections among presumptive TB patients who submitted samples to the study. The distribution by sex shows that more men had MOTT infections than women. However, all the risk factors listed for the study were not significant for MOTT infections. The recommendation is to improve the testing techniques to identify these microorganisms, which are neglected but very difficult to assess, especially when no clear population is at risk of getting these infections compared with TB.

Abstract Image

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马拉维Karonga地区结核病推定患者中非结核分枝杆菌的流行、分布和危险因素

简介：除了结核病（TB），还有其他非结核分枝杆菌（NTM）表现出与结核病相似的临床体征和症状。如果不及时发现和治疗，这些微生物可能会影响结核病控制和消除运动的规划。该研究试图确定Karonga地区推定结核病患者中MOTT感染的患病率、分布和因素。方法：采用描述性横断面研究设计。通过人口普查的方法，共有196名参与者参与了这项研究。通过对卫生保健工作者进行问卷调查收集数据，并收集参与者的痰标本；该标本用于显微镜检查分枝杆菌的存在。无论区级实验室的结果如何，所有标本随后都被送往Mzuzu地区结核病参比实验室，以分离结核分枝杆菌和非结核分枝杆菌。结果：196份样本中，14份（7.1%）呈区级阳性。送去培养时，195例（99.5%）有培养结果，23例（12%）培养有生长。在23例（100%）培养阳性结果中，12例（52%）为mtt阳性，11例（48%）为MTB复合物。mott阳性的男性为7人（58%），女性为5人（42%），15-39岁年龄组较多，6人（50%），60岁以上年龄组较少，2人（16.7%）。结论：结果显示，在提交样本的推定结核病患者中存在MOTT感染。按性别划分的分布表明，男性感染MOTT的人数多于女性。然而，该研究列出的所有危险因素对MOTT感染的影响并不显著。建议改进检测技术，以识别这些被忽视但很难评估的微生物，特别是当没有明确的人群与结核病相比有感染这些微生物的风险时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)