The Prevalence of Cardiovascular Disease Risk Factors on Diabetic Human Immunodeficiency Virus-Infected Individuals on Antiretroviral Treatment: A Systematic Review and Meta-Analysis Protocol

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-09-16 DOI:10.1002/hsr2.71274

Khanyisa Maswanganyi, Amogelang Sedibe, Nomusa Christina Mzimela, Mlindeli Gamede

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Abstract

Background and Aims

People with human immunodeficiency virus (PLWHIV) have a higher prevalence of non-communicable diseases (NCDs) such as obesity, diabetes mellitus and cardiovascular diseases (CVDs). Previous studies have depicted that PLWHIV have these NCDs due to the predisposing risk factors of CVDs including dyslipidaemia, impaired fasting glucose, hypertension, obesity, and elevated glycated hemoglobin. Understanding the cumulative consequences of these disorders is critical in this population. Hence, the aim of this protocol is to narrate the methods and techniques that will be used to perform a systematic review and meta-analysis of the prevalence of various CVD risk factors among diabetic individuals receiving antiretroviral therapy. Furthermore, this review will explore the extent to which traditional and HIV-specific risk factors contribute to the beginning and progression of CVD in the HIV-positive population by merging available data.

Methods

Literature search will be conducted using selected keywords on databases such as PubMed, Google Scholar, Scopus, and Web of science to identify eligible publications according to the eligibility criteria. Preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines will be used for reporting and risk of bias will be assessed using the Cochrane Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I tool). Data synthesis and sensitivity analysis will be performed using RevMan software and strength of evidence will be assessed using the grading of recommendations assessment, development, and evaluation approach (GRADE) pro tool.

Ethical Considerations and Registration

This systematic review protocol is registered with PROSPERO (CRD42024524396) and it doesn't require any ethical clearance as it will use data from published reports.

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接受抗逆转录病毒治疗的糖尿病人免疫缺陷病毒感染者心血管疾病危险因素的患病率：一项系统评价和荟萃分析方案

背景与目的：人类免疫缺陷病毒（PLWHIV）感染者具有较高的非传染性疾病（NCDs）患病率，如肥胖、糖尿病和心血管疾病（cvd）。先前的研究表明，由于心血管疾病的易感危险因素，包括血脂异常、空腹血糖受损、高血压、肥胖和糖化血红蛋白升高，PLWHIV具有这些非传染性疾病。了解这些疾病的累积后果对这一人群至关重要。因此，本方案的目的是叙述将用于对接受抗逆转录病毒治疗的糖尿病患者中各种心血管疾病危险因素的患病率进行系统回顾和荟萃分析的方法和技术。此外，本综述将通过合并现有数据，探讨传统和hiv特异性危险因素对hiv阳性人群CVD的开始和进展的影响程度。方法：在PubMed、b谷歌Scholar、Scopus、Web of science等数据库中选择关键词进行文献检索，根据入选标准筛选出符合条件的出版物。系统评价和荟萃分析（PRISMA）指南的首选报告项目将用于报告，偏倚风险将使用Cochrane非随机干预研究的偏倚风险（ROBINS-I工具）进行评估。数据综合和敏感性分析将使用RevMan软件进行，证据强度将使用推荐评估、开发和评估方法（GRADE） pro工具进行评估。伦理考虑和注册：本系统评价方案已在PROSPERO注册（CRD42024524396），不需要任何伦理许可，因为它将使用已发表报告的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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