Global burden of early-onset Parkinson's disease, 1990-2021: results from the Global Burden of Disease Study 2021.

IF 7.5 1区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology, Neurosurgery, and Psychiatry Pub Date : 2025-09-18 DOI:10.1136/jnnp-2024-335535

Qiwei Ji, Zujie Chen, Yuning Ma, Qing Guan, Feifan Chu, Lumin Chen, Jinzhong Ji, Mingxin Sun, Gaozhan Ren, Tingyang Huang, Haihan Song, Xiaojun Xu, Xiuquan Lin, Hao Zhou

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引用次数: 0

Abstract

Objectives: Early-onset Parkinson's disease (EOPD) is an increasingly serious disorder, yet there is currently a scarcity of epidemiological data and reports on this disease worldwide.

Methods: By using data from the 2021 Global Burden of Disease Study, we analysed the number of incident cases, prevalent cases and years lived with disability (YLDs) for EOPD (diagnosis after the age of 20 years and before the age of 50 years) from 1990 to 2021, along with their corresponding age-standardised rates. Additionally, we calculated the average annual percent change of the age-standardised rates and analysed the negative correlation between smoking and the disability-adjusted life years (DALYs) burden for EOPD.

Results: From 1990 to 2021, the incidence, prevalence and YLDs associated with EOPD have tripled globally. Most countries have seen a consistent increase in the age-standardised incidence and prevalence rates of this disease, especially those with high-middle Socio-Demographic Index scores. In 2021, smoking contributed to a 9.03% decrease in the global burden of DALYs, a decline from -14.14% in 1990.

Conclusions: EOPD is increasing at an alarming rate worldwide, necessitating the attention of global health organisations and the implementation of effective intervention measures to address this serious challenge.

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早发性帕金森病的全球负担，1990-2021：来自2021年全球疾病负担研究的结果

目的：早发性帕金森病（EOPD）是一种日益严重的疾病，但目前世界范围内关于该疾病的流行病学数据和报告缺乏。方法：通过使用2021年全球疾病负担研究（Global Burden of Disease Study）的数据，我们分析了1990年至2021年EOPD（20岁后和50岁前诊断）的发病病例数、流行病例数和残疾生活年限（YLDs），以及相应的年龄标准化率。此外，我们计算了年龄标准化率的平均年变化百分比，并分析了吸烟与EOPD的残疾调整生命年（DALYs）负担之间的负相关关系。结果：从1990年到2021年，全球EOPD的发病率、患病率和YLDs增加了两倍。大多数国家的这种疾病的年龄标准化发病率和流行率持续上升，特别是那些社会人口指数得分中高的国家。2021年，吸烟使全球伤残调整生命年负担减少了9.03%，低于1990年的-14.14%。结论：EOPD在世界范围内以惊人的速度增长，需要引起全球卫生组织的注意，并采取有效的干预措施来应对这一严重挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurology, Neurosurgery, and Psychiatry 医学-精神病学

CiteScore

15.70

自引率

1.80%

发文量

888

审稿时长

6 months

期刊介绍： The Journal of Neurology, Neurosurgery & Psychiatry (JNNP) aspires to publish groundbreaking and cutting-edge research worldwide. Covering the entire spectrum of neurological sciences, the journal focuses on common disorders like stroke, multiple sclerosis, Parkinson’s disease, epilepsy, peripheral neuropathy, subarachnoid haemorrhage, and neuropsychiatry, while also addressing complex challenges such as ALS. With early online publication, regular podcasts, and an extensive archive collection boasting the longest half-life in clinical neuroscience journals, JNNP aims to be a trailblazer in the field.