Extracellular Vesicles in Skin: Biological Function and Therapeutic Potential.

IF 6.5 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-09-13 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S548986

Siqi Yuan, Mengyu Jin, Yanyan Zhang, Mengting Zhang, Minjia Yuan, Xiaolei Ding, Juan Wang

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Abstract

Extracellular vesicles (EVs) are nanoscale, lipid bilayer-enclosed particles containing bioactive molecules that play crucial roles in tissue homeostasis. These vesicles regulate cellular functions via delivery of protein, lipid, and nucleic acid cargos to target cells, thereby orchestrating essential biological processes, including cellular proliferation, activation, angiogenesis, and immune responses. The past decade has witnessed unprecedented growth in research examining EV functions in cutaneous physiology and pathogenesis. Here, we describe the biogenesis, composition and cellular uptake of EVs, critically highlighting the therapeutic effects and potential mechanisms of EVs from mammalian, plant and bacterial cells in skin diseases, including skin wound healing, hair growth, aging, inflammatory diseases and cancers. In addition, we discuss clinical translation challenges and outline future research directions for advancing EV-based therapeutics in clinical dermatology.

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皮肤细胞外囊泡：生物学功能和治疗潜力。

细胞外囊泡（EVs）是一种纳米级的脂质双层封闭颗粒，含有生物活性分子，在组织稳态中起着至关重要的作用。这些囊泡通过将蛋白质、脂质和核酸货物运送到靶细胞来调节细胞功能，从而协调必要的生物过程，包括细胞增殖、活化、血管生成和免疫反应。在过去的十年中，研究EV在皮肤生理和发病机制中的功能取得了前所未有的发展。在这里，我们描述了ev的生物发生、组成和细胞摄取，重点强调了来自哺乳动物、植物和细菌细胞的ev在皮肤疾病（包括皮肤伤口愈合、毛发生长、衰老、炎症性疾病和癌症）中的治疗作用和潜在机制。此外，我们还讨论了临床翻译面临的挑战，并概述了未来在临床皮肤病学中推进基于ev的治疗的研究方向。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.