Diagnostic Significance of Hematological Parameters and Ratios in the Context of Mycobacterium Avium Complex Pulmonary Disease Across Various Age Groups.
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Abstract
Objective: This investigation intends to clarify the disparities in hematological parameters and ratios among different age groups,providing new insights for the diagnostic of Mycobacterium Avium Complex Pulmonary Disease (MAC-PD).
Patients and methods: A retrospective investigation was undertaken to examine the hematological parameters of elderly (n=88) and non-elderly (n=44) patients diagnosed with MAC-PD at Hebei Chest Hospital between 2020 and 2024. The study involved the calculation of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), hemoglobin-to-lymphocyte ratio (HLR),hemoglobin-to-platelet ratio (HPR),systemic inflammatory response index (SIRI) and systemic immune-inflammation index (SII). Statistical analyses were executed utilizing SPSS 27.0 and R (4.2.1) software.
Results: The levels of absolute lymphocyte count (ALC),hemoglobin (Hb) and LMR were lower in Elderly MAC group compared to Non-elderly MAC group. Conversely,the levels of NLR, PLR,HLR,SIRI and SII were higher in Elderly MAC group than in Non-elderly MAC group. There was a certain correlation between the Ct value of MAC nucleic acid and NLR, LMR, SIRI and SII (P<0.05) in Elderly MAC group. In Non-elderly MAC group, the Ct value of MAC nucleic acid was correlated with absolute neutrophil count (ANC), LMR, SIRI and SII (P<0.05). Receiver operating characteristic curve (ROC) analysis indicated that NLR, LMR, SIRI and SII exhibited high diagnostic value in Elderly MAC group,while LMR, SIRI and SII demonstrated high diagnostic value in Non-elderly MAC group. The combined diagnostic value was even more prominent. Nevertheless,no significant diagnostic indicators were identified between Elderly MAC group and Non-elderly MAC group.
Conclusion: The combination of NLR, LMR, SIRI and SII may serve as diagnostic markers for Elderly MAC-PD and the combination of LMR, SIRI and SII may serve as diagnostic markers for Non-lderly MAC-PD. But there were no significant diagnostic indicators differentiating Elderly MAC group from Non-elderly MAC group.
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Editor-in-Chief: Professor Suresh Antony
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