Bidirectional causal association between frailty and six psychiatric disorders.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-09-19 DOI:10.1007/s00406-025-02098-6

Fangfang Qian, Guoqiang Zheng, Zhuoming Chen

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引用次数: 0

Abstract

Background: This study employs bidirectional Mendelian randomization (MR) analysis to explore the causal relationship between frailty and common psychiatric disorders.

Methods: Depression, anxiety disorder, bipolar disorder, schizophrenia, sleep disorders, and eating disorders were considered as outcomes, with frailty index as the exposure variable. The main method employed was inverse variance weighting. Two-step MR was used to evaluate the mediation proportions of body mass index (BMI) between frailty and psychiatric disorders. Additionally, reverse MR analysis was conducted using the same testing methods.

Results: Frailty index was positively associated with depression, anxiety disorder, bipolar disorder, sleep disorders, and eating disorders. Schizophrenia indicated no significant causal association. The effect of frailty index on the risk of sleep disorders, eating disorders, depression were all partially mediated by BMI, with mediation proportion of 24.40%, 14.23% and 5.22%. Reverse MR analysis revealed that depression increased the risk of frailty.

Conclusion: This study has supported the causal association of frailty with depression, anxiety disorder, bipolar disorder, sleep disorders, and eating disorders. Additionally, individuals diagnosed with depression exhibit a heightened susceptibility to frailty. This sheds new light on the causal relationship between frailty and psychiatric disorders.

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虚弱与六种精神疾病之间的双向因果关系。

背景：本研究采用双向孟德尔随机化（MR）分析来探讨虚弱与常见精神疾病之间的因果关系。方法：将抑郁、焦虑障碍、双相情感障碍、精神分裂症、睡眠障碍和饮食障碍作为结局，以虚弱指数为暴露变量。采用的主要方法是方差逆加权。采用两步磁共振评价体质指数（BMI）在虚弱和精神障碍之间的中介比例。此外，采用相同的检测方法进行反向MR分析。结果：虚弱指数与抑郁、焦虑障碍、双相情感障碍、睡眠障碍和饮食障碍呈正相关。精神分裂症没有明显的因果关系。体质指数对睡眠障碍、饮食障碍、抑郁风险的影响均被BMI部分介导，其中介比例分别为24.40%、14.23%和5.22%。反向核磁共振分析显示，抑郁会增加身体虚弱的风险。结论：这项研究支持了虚弱与抑郁、焦虑障碍、双相情感障碍、睡眠障碍和饮食障碍的因果关系。此外，被诊断为抑郁症的人表现出对脆弱的高度敏感性。这为脆弱和精神疾病之间的因果关系提供了新的线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.