Augustė Andzelytė, Ieva Tveragaitė, Povilas Ignatavicius
{"title":"Surgery for multifocal intrahepatic cholangiocarcinoma.","authors":"Augustė Andzelytė, Ieva Tveragaitė, Povilas Ignatavicius","doi":"10.1159/000548043","DOIUrl":null,"url":null,"abstract":"<p><p>Background Multifocal intrahepatic cholangiocarcinoma (m-ICC) is an aggressive form of primary liver cancer, often associated with poor outcomes. Although surgical resection is considered the only curative treatment for ICC, multifocality is frequently regarded as a contraindication due to the high risk of recurrence and limited survival benefits. Aim To perform a systematic literature review on the outcomes of surgical treatment of m-iCCA. Methods This systematic review was performed according to PRISMA statement. A study protocol for the review was registered in the International Prospective Register of Systematic Reviews database. Databases were systematically searched for studies analysing surgical treatment outcomes for m-iCCA. Results Ten articles with 2392 patients who had m-ICCA were included in our review. The reviewed studies reported extensive surgical procedures with median survival ranging from 18.9 to 27 months. Recurrence rates were higher in m-iCCA patients (67.8-74.3%) compared to solitary ICC cases (52.4-60.5%), with recurrence-free survival as short as 4.5 months. One study reported a 5-year survival rate of 12.9% for surgical patients compared to 0% for non-operated patients. Survival outcomes were influenced by adverse prognostic indicators. Conclusions Surgical resection for multifocal intrahepatic cholangiocarcinoma is a challenging treatment option due to the high likelihood of recurrence and the aggressive nature of the disease. Despite these challenges, surgery may offer survival benefits for carefully selected patients.</p>","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":" ","pages":"1-16"},"PeriodicalIF":1.2000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548043","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background Multifocal intrahepatic cholangiocarcinoma (m-ICC) is an aggressive form of primary liver cancer, often associated with poor outcomes. Although surgical resection is considered the only curative treatment for ICC, multifocality is frequently regarded as a contraindication due to the high risk of recurrence and limited survival benefits. Aim To perform a systematic literature review on the outcomes of surgical treatment of m-iCCA. Methods This systematic review was performed according to PRISMA statement. A study protocol for the review was registered in the International Prospective Register of Systematic Reviews database. Databases were systematically searched for studies analysing surgical treatment outcomes for m-iCCA. Results Ten articles with 2392 patients who had m-ICCA were included in our review. The reviewed studies reported extensive surgical procedures with median survival ranging from 18.9 to 27 months. Recurrence rates were higher in m-iCCA patients (67.8-74.3%) compared to solitary ICC cases (52.4-60.5%), with recurrence-free survival as short as 4.5 months. One study reported a 5-year survival rate of 12.9% for surgical patients compared to 0% for non-operated patients. Survival outcomes were influenced by adverse prognostic indicators. Conclusions Surgical resection for multifocal intrahepatic cholangiocarcinoma is a challenging treatment option due to the high likelihood of recurrence and the aggressive nature of the disease. Despite these challenges, surgery may offer survival benefits for carefully selected patients.
期刊介绍:
''Digestive Surgery'' presents a comprehensive overview in the field of gastrointestinal surgery. Interdisciplinary in scope, the journal keeps the specialist aware of advances in all fields that contribute to improvements in the diagnosis and treatment of gastrointestinal disease. Particular emphasis is given to articles that evaluate not only recent clinical developments, especially clinical trials and technical innovations such as new endoscopic and laparoscopic procedures, but also relevant translational research. Each contribution is carefully aligned with the need of the digestive surgeon. Thus, the journal is an important component of the continuing medical education of surgeons who want their practice to benefit from a familiarity with new knowledge in all its dimensions.