Performance of Fecal Immunochemical Test in Individuals With Personal history of Polyps and Family History of Colorectal Cancer: A Systematic Review.

IF 12 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Clinical Gastroenterology and Hepatology Pub Date : 2025-09-16 DOI:10.1016/j.cgh.2025.09.013

Rahul Karna, Mohammad Bilal, Tarek Nayfeh, Azizullah Beran, Ruchir Paladiya, Himsikhar Khataniar, Ravishankar Ranganatha, Nicole Theis-Mahon, Samir Gupta, Aasma Shaukat

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引用次数: 0

Abstract

Background & aims: There is limited information regarding performance of fecal immunochemical test (FIT) in post-polypectomy surveillance, or for screening individuals with a family history of colorectal cancer (CRC). We conducted a systematic review to assess current evidence regarding diagnostic performance of one time FIT in increased risk populations.

Methods: A comprehensive search of multiple databases was conducted to assess studies reporting performance of a one-time FIT as screening or surveillance tool in individuals at increased risk of CRC.

Results: We identified 3 studies reporting on 8817 individuals with personal history of polyps who underwent FIT testing. For CRC detection, one-time FIT showed sensitivity ranging from 27.6% to 100.0% and specificity ranging from 55.9% to 94.1% with variable test thresholds and index polyp histology. We identified 12 studies reporting on 5525 individuals with family history of CRC. One-time FIT showed a sensitivity ranging from 25.0% to 100.0% and specificity ranging from 83.1% to 92.0%, with variable test thresholds and family history characteristics.

Conclusion: Current evidence is limited to adequately assess diagnostic performance of FIT in individuals with family history of CRC, or as follow-up after polypectomy.

查看原文本刊更多论文

有息肉病史和结直肠癌家族史的人粪便免疫化学试验的表现：系统回顾。

背景和目的：关于粪便免疫化学试验（FIT）在息肉切除术后监测或筛查有CRC家族史的个体中的表现的信息有限。我们进行了一项系统综述，以评估关于一次性FIT在高危人群中的诊断性能的现有证据。方法：对多个数据库进行全面搜索，以评估报告一次性FIT作为CRC风险增加个体筛查或监测工具的效果的研究。结果：我们确定了三项研究，报告了8817名接受FIT测试的有息肉病史的个体。对于结直肠癌的检测，在不同的检测阈值和指数息肉组织学下，一次FIT的灵敏度为27.6% - 100.0%，特异性为55.9% - 94.1%。我们确定了12项研究，报告了5525例有CRC家族史的个体。一次FIT的敏感性为25.0% ~ 100.0%，特异性为83.1% ~ 92.0%，具有不同的检测阈值和家族史特征。结论：目前的证据仅限于充分评估FIT在有CRC家族史的个体中的诊断性能，或作为息肉切除术后的随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Gastroenterology and Hepatology 医学-胃肠肝病学

CiteScore

16.90

自引率

4.80%

发文量

903

审稿时长

22 days

期刊介绍： Clinical Gastroenterology and Hepatology (CGH) is dedicated to offering readers a comprehensive exploration of themes in clinical gastroenterology and hepatology. Encompassing diagnostic, endoscopic, interventional, and therapeutic advances, the journal covers areas such as cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion. As a peer-reviewed publication, CGH features original articles and scholarly reviews, ensuring immediate relevance to the practice of gastroenterology and hepatology. Beyond peer-reviewed content, the journal includes invited key reviews and articles on endoscopy/practice-based technology, health-care policy, and practice management. Multimedia elements, including images, video abstracts, and podcasts, enhance the reader's experience. CGH remains actively engaged with its audience through updates and commentary shared via platforms such as Facebook and Twitter.