Case report: Donor-derived clonal haematopoiesis after allogeneic stem cell transplantation.

IF 1.1 4区医学 Q3 HEMATOLOGY

Acta Haematologica Pub Date : 2025-09-18 DOI:10.1159/000548473

Adrian Schwarzer, Christian Späth, Thomas Neumann, Jan Krönke, William H Krüger

引用次数: 0

Abstract

The accidental transmission of malignant and non-malignant hematological diseases through allogeneic hematopoietic cell transplantation has been described. Next-generation sequencing facilitates the detection of a wide range of mutations in suspected myeloid diseases. The transfer of clonal haematopoiesis is not uncommon and raises important medical and ethical considerations. We present two cases of donor-derived clonal haematopoiesis (CHIP) following allogeneic stem cell transplantation. In one case, the establishment of donor-derived CHIP was stabilized by donor-lymphocyte infusions given to counteract declining donor chimerism.

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病例报告：同种异体干细胞移植后供体来源的克隆造血。

恶性和非恶性血液病的意外传播通过异体造血细胞移植已被描述。新一代测序有助于在疑似髓系疾病中检测广泛的突变。克隆造血的转移并不罕见，并引起了重要的医学和伦理考虑。我们报告了两例异体干细胞移植后的供体衍生克隆造血（CHIP）。在一个病例中，通过输注供体淋巴细胞来抵消供体嵌合的下降，供体衍生CHIP的建立得到了稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Haematologica 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.