Advancements in antiviral activity of aza-heterocyclic compounds: a review.

IF 3.8 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2025-09-19 DOI:10.1007/s11030-025-11355-8

Issam Ameziane El Hassani, Khalid Karrouchi, M'hammed Ansar

引用次数: 0

Abstract

Aza-heterocycles serve as privileged scaffolds in antiviral drug discovery due to their versatile chemical tunability and broad-spectrum biological activities. Strategic structural modifications of these pharmacophores have emerged as a powerful approach to optimize therapeutic potential, enabling the development of novel bioactive agents. These nitrogen-containing heterocycles demonstrate remarkable pharmacological diversity, exhibiting efficacy as anti-inflammatory, antimicrobial, antidiabetic, and anticancer compounds, along with enzyme inhibitory and pesticidal properties. This review systematically evaluates 5- and 6-membered aza-heterocyclic systems with established antiviral profiles, highlighting structure-activity relationships. The synthesized insights will advance research in synthetic organic chemistry, medicinal chemistry, and pharmacological development of next-generation therapeutics.

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偶氮杂环化合物抗病毒活性的研究进展。

偶氮杂环化合物具有广泛的化学可调性和广谱的生物活性，在抗病毒药物开发中具有良好的应用前景。这些药效团的战略性结构修饰已成为优化治疗潜力的有力方法，使新型生物活性药物的开发成为可能。这些含氮杂环化合物表现出显著的药理多样性，具有抗炎、抗菌、抗糖尿病和抗癌的功效，同时具有酶抑制和杀虫特性。本综述系统地评价了具有已建立的抗病毒谱的5-和6-元偶氮杂环系统，突出了结构-活性关系。合成的见解将推动合成有机化学，药物化学和下一代治疗药物的药理学发展的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;