Methyl gallate-loaded platelet-mimetic liposome for targeted therapy of ulcerative colitis

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-12 DOI:10.1016/j.colsurfb.2025.115141

Lu Wang , Qingze Fan , Zhigang Chen , Tianci Li , Xiaoxuan Li , Qiaozhi Wang , Ruizhi Tan , Lishang Liao , Wenjun Zou , Jianming Wu , Shengli Wan

{"title":"Methyl gallate-loaded platelet-mimetic liposome for targeted therapy of ulcerative colitis","authors":"Lu Wang , Qingze Fan , Zhigang Chen , Tianci Li , Xiaoxuan Li , Qiaozhi Wang , Ruizhi Tan , Lishang Liao , Wenjun Zou , Jianming Wu , Shengli Wan","doi":"10.1016/j.colsurfb.2025.115141","DOIUrl":null,"url":null,"abstract":"<div><div>Ulcerative colitis (UC) is a persistent inflammatory bowel disease that poses an increasingly significant public health concern worldwide. Given the limited efficacy of current therapies, the development of novel treatment approaches has become increasingly urgent. Our previous investigation established that methyl gallate (MG) exhibits therapeutic potential for UC due to its effective anti-inflammatory properties. However, the low targeting specificity and high <em>in vivo</em> clearance rate of MG restrict its application. Herein, platelet membrane (PM) biomimetic MG-loaded liposome (PML) was firstly constructed to improve MG delivery and enable targeted UC therapy. Due to the PM cloaking, PML exhibited prolonged circulation time and enhanced targeting to damaged colon caused by UC. Moreover, the PM biomimetic liposome demonstrated higher uptake efficiency in inflammatory cells. <em>In vitro</em> and <em>in vivo</em> investigations consistently proved that PML exhibited significant anti-inflammatory activity. Additionally, intravenous administration of PML effectively reduced disease severity in UC mouse models and promoted the intestinal tissue repair. Besides, PML showed high erythrocyte compatibility and favorable biosafety in UC mice and zebrafish. Collectively, PML achieve enhanced MG delivery and may provide a novel precision therapy strategy for UC treatment.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"257 ","pages":"Article 115141"},"PeriodicalIF":5.6000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces B: Biointerfaces","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927776525006484","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}

引用次数: 0

Abstract

Ulcerative colitis (UC) is a persistent inflammatory bowel disease that poses an increasingly significant public health concern worldwide. Given the limited efficacy of current therapies, the development of novel treatment approaches has become increasingly urgent. Our previous investigation established that methyl gallate (MG) exhibits therapeutic potential for UC due to its effective anti-inflammatory properties. However, the low targeting specificity and high in vivo clearance rate of MG restrict its application. Herein, platelet membrane (PM) biomimetic MG-loaded liposome (PML) was firstly constructed to improve MG delivery and enable targeted UC therapy. Due to the PM cloaking, PML exhibited prolonged circulation time and enhanced targeting to damaged colon caused by UC. Moreover, the PM biomimetic liposome demonstrated higher uptake efficiency in inflammatory cells. In vitro and in vivo investigations consistently proved that PML exhibited significant anti-inflammatory activity. Additionally, intravenous administration of PML effectively reduced disease severity in UC mouse models and promoted the intestinal tissue repair. Besides, PML showed high erythrocyte compatibility and favorable biosafety in UC mice and zebrafish. Collectively, PML achieve enhanced MG delivery and may provide a novel precision therapy strategy for UC treatment.

查看原文本刊更多论文

载没食子酸甲酯的血小板模拟脂质体用于溃疡性结肠炎的靶向治疗。

溃疡性结肠炎（UC）是一种持续性炎症性肠病，在世界范围内引起越来越多的公共卫生关注。鉴于目前治疗方法的疗效有限，开发新的治疗方法变得越来越迫切。我们之前的研究表明，由于其有效的抗炎特性，没食子酸甲酯（MG）具有治疗UC的潜力。然而，MG的低靶向特异性和高体内清除率限制了其应用。本文首先构建了血小板膜（PM）仿生载MG脂质体（PML），以改善MG的递送并实现靶向UC治疗。由于PM的隐蔽性，PML表现出延长循环时间和增强对UC引起的结肠损伤的靶向性。此外，PM仿生脂质体在炎症细胞中表现出更高的摄取效率。体外和体内研究一致证明PML具有显著的抗炎活性。此外，静脉给药PML可有效降低UC小鼠模型的疾病严重程度，促进肠道组织修复。此外，PML在UC小鼠和斑马鱼中表现出较高的红细胞相容性和良好的生物安全性。总的来说，PML增强了MG的传递，并可能为UC治疗提供新的精确治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.