Genetic factors for hematological traits in pigs

IF 2.1 3区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal genetics Pub Date : 2025-09-19 DOI:10.1111/age.70043

Jiahong Sun, Emil Ibragimov, Peter Karlskov-Mortensen, Merete Fredholm

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Abstract

Complete blood count with differential is a critical diagnostic tool for evaluating the physiological and health status of individuals by analyzing white blood cells, red blood cells, and platelets. While extensively used in human medicine, the application of complete blood count biomarkers in pigs remain limited. This review focuses on the genetic architecture of hematological traits in pigs (Sus scrofa) using data from genetic association studies. By compiling data from multiple porcine studies, we identified 509 SNPs within 53 high-confidence QTL supported by more than one study. Among these, 37 QTL were homologous to human loci, with 19 containing plausible candidate genes likely to be influencing hematological traits. These genes are often linked to cytoskeletal formation, hematopoiesis, and immune function, highlighting conserved biological mechanisms across species. Our findings provide a foundation for further investigations into the genetic regulation of blood cell parameters in pigs and their implications for health, welfare, and production traits, offering potential translational insights for both veterinary and human medicine.

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猪血液学性状的遗传因素。

全血细胞计数是一种重要的诊断工具，通过分析白细胞、红细胞和血小板来评估个体的生理和健康状况。虽然在人类医学中广泛使用，但全血细胞计数生物标志物在猪中的应用仍然有限。本文利用遗传关联研究的数据对猪（Sus scrofa）血液学性状的遗传结构进行了综述。通过汇编来自多个猪研究的数据，我们在53个高置信度QTL中鉴定出509个snp，这些QTL得到了多个研究的支持。其中，37个QTL与人类基因座同源，19个QTL含有可能影响血液学性状的候选基因。这些基因通常与细胞骨架形成、造血和免疫功能有关，强调了跨物种的保守生物学机制。我们的研究结果为进一步研究猪血细胞参数的遗传调控及其对健康、福利和生产性状的影响奠定了基础，为兽医和人类医学提供了潜在的转化见解。

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来源期刊

Animal genetics 生物-奶制品与动物科学

CiteScore

4.60

自引率

4.20%

发文量

115

审稿时长

5 months

期刊介绍： Animal Genetics reports frontline research on immunogenetics, molecular genetics and functional genomics of economically important and domesticated animals. Publications include the study of variability at gene and protein levels, mapping of genes, traits and QTLs, associations between genes and traits, genetic diversity, and characterization of gene or protein expression and control related to phenotypic or genetic variation. The journal publishes full-length articles, short communications and brief notes, as well as commissioned and submitted mini-reviews on issues of interest to Animal Genetics readers.