Molecular Imaging of Diabetes-Associated Glutathione S-Transferase Dysregulation Using a Smart Activatable Probe

IF 3.9 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-09-18 DOI:10.1021/acs.bioconjchem.5c00417

Jian He, , , Dake Wen, , , Linv Xia*, , , Zhigang Hu*, , and , Kai Wang*,

引用次数: 0

Abstract

We developed a dual-modal GSTP probe that exhibits GST-responsive fluorescence enhancement and photoacoustic signal reduction. GSTP demonstrated excellent selectivity, sensitivity, and biocompatibility. In diabetic mice, GSTP revealed a decreased level of hepatic GST activity partially restored by metformin treatment, supported by serum analysis and histopathological evaluation, highlighting its clinical translation potential for diabetes monitoring.

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使用智能激活探针对糖尿病相关谷胱甘肽s-转移酶失调进行分子成像。

我们开发了一种双模态GSTP探针，具有gst响应荧光增强和光声信号减少。GSTP具有良好的选择性、敏感性和生物相容性。在糖尿病小鼠中，GSTP显示了二甲双胍治疗后肝脏GST活性部分恢复的降低水平，这得到了血清分析和组织病理学评估的支持，突出了其在糖尿病监测中的临床转化潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.