Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-19 DOI:10.1002/alz.70651

Corey J. Bolton, Panpan Zhang, Devika Nair, Dandan Liu, L. Taylor Davis, Kimberly R. Pechman, Niranjana Shashikumar, Sydney Wilhoite, Dominic Roby, Carlie Beeson, Haley Komorowski, Katherine A. Gifford, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson

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Abstract

INTRODUCTION

The impact of chronic kidney disease (CKD) on Alzheimer's disease (AD) plasma biomarkers is poorly understood. We tested whether kidney function decline affects the predictive accuracy of plasma biomarkers on neuropsychological or neuroimaging outcomes.

METHODS

Three hundred thirty-three non-demented older adults were included. Linear regressions related plasma glial fibrillary acidic protein, neurofilament light chain (NfL), amyloid beta 42, and phosphorylated tau₂₃₁, with a blood-based biomarker x estimated glomerular filtration rate (eGFR) interaction term, to cross-sectional and longitudinal (mean follow-up time = 6.4 ± 2.8 years) neuropsychological and neuroimaging outcomes.

RESULTS

Plasma NfL interacted with eGFR on the longitudinal trajectory of nearly all neuropsychological outcomes (p values < 0.02) and several neuroimaging outcomes (p values < 0.02). Associations were stronger in individuals with no CKD/stage 1 and stage 2 CKD, while associations were weaker or not significant in individuals with stage 3 CKD.

DISCUSSION

Among older adults free of severe CKD, the ability of plasma NfL to predict key AD-related biomarker outcomes was moderated by renal function.

Highlights

Reduced kidney function was associated with increased blood biomarker levels.
The predictive accuracy of neurofilament light chain was reduced in participants with kidney dysfunction.
Even mild kidney dysfunction can affect blood biomarkers of Alzheimer's disease.

Abstract Image

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在9年的随访期间，轻度肾功能不全影响基于血液的生物标志物对神经心理学和神经影像学结果的预测准确性

慢性肾脏疾病（CKD）对阿尔茨海默病（AD）血浆生物标志物的影响尚不清楚。我们测试了肾功能下降是否会影响血浆生物标志物对神经心理学或神经影像学结果的预测准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.