Association between cardiovascular and cognitive health among older Indigenous Africans: Data from an urban Nigerian settlement participating in the VALIANT study

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-18 DOI:10.1002/alz.70669

Rufus O. Akinyemi, Oladotun V. Olalusi, Gabriel O. Ogunde, Tolulope O. Akinyemi, Joseph O. Yaria, Olabode Oguntiloye, Ayotomiwa Fagbemi, Eniola O. Cadmus, Femi O. Popoola, Mayowa Ogunronbi, Dorcas Olujobi, Olaoluwa Famuyiwa, Joshua O. Akinyemi, Mayowa O. Owolabi, Roman Romero-Ortuno, Adesola Ogunniyi, Rajesh N. Kalaria, Brian Lawlor

{"title":"Association between cardiovascular and cognitive health among older Indigenous Africans: Data from an urban Nigerian settlement participating in the VALIANT study","authors":"Rufus O. Akinyemi, Oladotun V. Olalusi, Gabriel O. Ogunde, Tolulope O. Akinyemi, Joseph O. Yaria, Olabode Oguntiloye, Ayotomiwa Fagbemi, Eniola O. Cadmus, Femi O. Popoola, Mayowa Ogunronbi, Dorcas Olujobi, Olaoluwa Famuyiwa, Joshua O. Akinyemi, Mayowa O. Owolabi, Roman Romero-Ortuno, Adesola Ogunniyi, Rajesh N. Kalaria, Brian Lawlor","doi":"10.1002/alz.70669","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>The relationship between cardiovascular health (CVH) and cognitive health (CH) has been established in diverse populations but is understudied among indigenous Africans. We investigated the association between CVH and CH in 1031 older Nigerian Africans participating in the Vascular heAlth, fraiLty, and cognItion in Ageing Nigerians sTudy (VALIANT).</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>CVH was assessed by the Life's Simple 7 (LS7) score. CH was measured using three validated metrics of general cognitive well-being: Montreal Cognitive Assessment (MoCA), Community Screening Instrument for Dementia (CSID), and Identification and Intervention for Dementia in Elderly Africans (IDEA). Frailty was evaluated using Rockwood's Clinical Frailty Scale. Multivariable linear regression was performed.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Individual LS7 metrics, including poor diet, ideal body mass index (overall), and intermediate blood pressure (among female participants), showed independent relationships with poor CH. Although the LS7 composite score showed a significant univariate relationship with MoCA and IDEA scores, the independent determinants of general CH were older age, low educational attainment, and clinical frailty, but not LS7 composite score</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>In a sample of older Nigerian Africans, the LS7 composite score may not accurately characterize the relationship between CVH and CH. Afrocentric CVH composite scores incorporating measures that are more sensitive to outcomes in Africans are needed.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>We determined the association between cardiovascular health (CVH) and cognitive health (CH) in 1031 urban-dwelling Nigerian Africans.</li>\n \n <li>Although individual Life's Simple 7 (LS7) metrics such as poor diet, intermediate blood pressure, and ideal body mass index showed independent association with poor CH, the composite LS7 metric showed no association.</li>\n \n <li>In a sample of Nigerian Africans, the LS7 score as a composite vascular marker may not accurately characterize the relationship between CVH and CH.</li>\n \n <li>Afrocentric composite scores incorporating risk markers potentially unique to indigenous African populations are needed for robust characterization of CVH.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70669","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70669","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

The relationship between cardiovascular health (CVH) and cognitive health (CH) has been established in diverse populations but is understudied among indigenous Africans. We investigated the association between CVH and CH in 1031 older Nigerian Africans participating in the Vascular heAlth, fraiLty, and cognItion in Ageing Nigerians sTudy (VALIANT).

METHODS

CVH was assessed by the Life's Simple 7 (LS7) score. CH was measured using three validated metrics of general cognitive well-being: Montreal Cognitive Assessment (MoCA), Community Screening Instrument for Dementia (CSID), and Identification and Intervention for Dementia in Elderly Africans (IDEA). Frailty was evaluated using Rockwood's Clinical Frailty Scale. Multivariable linear regression was performed.

RESULTS

Individual LS7 metrics, including poor diet, ideal body mass index (overall), and intermediate blood pressure (among female participants), showed independent relationships with poor CH. Although the LS7 composite score showed a significant univariate relationship with MoCA and IDEA scores, the independent determinants of general CH were older age, low educational attainment, and clinical frailty, but not LS7 composite score

DISCUSSION

In a sample of older Nigerian Africans, the LS7 composite score may not accurately characterize the relationship between CVH and CH. Afrocentric CVH composite scores incorporating measures that are more sensitive to outcomes in Africans are needed.

Highlights

We determined the association between cardiovascular health (CVH) and cognitive health (CH) in 1031 urban-dwelling Nigerian Africans.
Although individual Life's Simple 7 (LS7) metrics such as poor diet, intermediate blood pressure, and ideal body mass index showed independent association with poor CH, the composite LS7 metric showed no association.
In a sample of Nigerian Africans, the LS7 score as a composite vascular marker may not accurately characterize the relationship between CVH and CH.
Afrocentric composite scores incorporating risk markers potentially unique to indigenous African populations are needed for robust characterization of CVH.

Abstract Image

查看原文本刊更多论文

老年非洲土著居民心血管和认知健康之间的关系：参与VALIANT研究的尼日利亚城市定居点的数据

心血管健康（CVH）与认知健康（CH）之间的关系已在不同人群中确立，但在非洲土著人群中尚未得到充分研究。我们调查了1031名参加尼日利亚老年人血管健康、虚弱和认知研究（VALIANT）的尼日利亚老年人CVH和CH之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.